空间免疫肿瘤学的最新进展。

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2025-02-01 Epub Date: 2024-12-19 DOI:10.1016/j.semcdb.2024.12.003

Alex To, Zou Yu, Ryohichi Sugimura

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引用次数: 0

摘要

空间转录组学和空间蛋白质组学的最新进展使得利用空间信息对单个或多个细胞类型和细胞状态进行高通量分析成为可能。他们改变了我们对肿瘤微环境（TME）中高阶结构和配对细胞-细胞相互作用的理解。在不到十年的时间里，这个快速发展的领域已经发现了许多重要的基础知识，并显著改善了免疫肿瘤学领域的临床诊断。本文综述了理解空间组学数据的概念框架，并重点介绍了空间免疫肿瘤学的最新知识。

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Recent advancement in the spatial immuno-oncology.

Recent advancements in spatial transcriptomics and spatial proteomics enabled the high-throughput profiling of single or multi-cell types and cell states with spatial information. They transformed our understanding of the higher-order architectures and paired cell-cell interactions within a tumor microenvironment (TME). Within less than a decade, this rapidly emerging field has discovered much crucial fundamental knowledge and significantly improved clinical diagnosis in the field of immuno-oncology. This review summarizes the conceptual frameworks to understand spatial omics data and highlights the updated knowledge of spatial immuno-oncology.

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.