致幻剂的风险需要更多的安全性数据才能在青少年中开始试验。

IF 9.2 1区医学 Q1 PEDIATRICS

Journal of the American Academy of Child and Adolescent Psychiatry Pub Date : 2024-12-19 DOI:10.1016/j.jaac.2024.12.001

Samuel Dotson, James Luccarelli

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引用次数: 0

摘要

我们饶有兴趣地阅读了杰弗里等人的评论，鼓励对青少年使用致幻剂进行临床研究在他们的整个评论中，作者都是在一个普遍的前提下运作的，即迷幻药已经证明了对成年人的良好安全性，因此，接近成人神经发育水平的青少年可能会得到安全的治疗，并采取适当的保护措施。尽管我们同意迫切需要针对青少年的新型精神药物，但我们质疑这种安全性假设，因为在成人试验中越来越多的证据表明与迷幻药相关的风险。

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Psychedelic Therapeutics for Adolescents: Ethics, Safety, Opportunities, and Equipoise.

We read with interest the Commentary by Jeffrey et al. encouraging clinical research using psychedelics for adolescents.¹ Throughout their commentary, the authors operate under the general presupposition that psychedelics have demonstrated a favorable safety profile in adults, and that therefore teenagers approaching an adult level of neurodevelopment can likely be safely treated with appropriate safeguards. Although we concur that there is an urgent need for new psychopharmaceuticals for adolescents, we question this assumption of safety, given increasing evidence of risks associated with psychedelics in adult trials.^2,3.

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来源期刊

Journal of the American Academy of Child and Adolescent Psychiatry 医学-精神病学

CiteScore

21.00

自引率

1.50%

发文量

1383

审稿时长

53 days

期刊介绍： The Journal of the American Academy of Child & Adolescent Psychiatry (JAACAP) is dedicated to advancing the field of child and adolescent psychiatry through the publication of original research and papers of theoretical, scientific, and clinical significance. Our primary focus is on the mental health of children, adolescents, and families. We welcome unpublished manuscripts that explore various perspectives, ranging from genetic, epidemiological, neurobiological, and psychopathological research, to cognitive, behavioral, psychodynamic, and other psychotherapeutic investigations. We also encourage submissions that delve into parent-child, interpersonal, and family research, as well as clinical and empirical studies conducted in inpatient, outpatient, consultation-liaison, and school-based settings. In addition to publishing research, we aim to promote the well-being of children and families by featuring scholarly papers on topics such as health policy, legislation, advocacy, culture, society, and service provision in relation to mental health. At JAACAP, we strive to foster collaboration and dialogue among researchers, clinicians, and policy-makers in order to enhance our understanding and approach to child and adolescent mental health.