Amanda Wilson, Neloufar Rahai, Ekkehard Beck, Elisha Beebe, Brian Conroy, Daina Esposito, Priya Govil, Hagit Kopel, Tianyi Lu, James Mansi, Morgan A Marks, Katherine E Mues, Rohan Shah, Michelle Skornicki, Tianyu Sun, Astra Toyip, Mitra Yousefi, David Martin, Andre B Araujo
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Adults vaccinated with mRNA-1273.815 between September 12, 2023, and December 31, 2023, were followed through January 26, 2024. Vaccinated individuals were matched with individuals unvaccinated with any 2023-2024 COVID-19 vaccine on demographic and clinical characteristics. The primary and secondary outcomes were COVID-19 hospitalization and medically attended COVID-19, respectively. Inverse probability of treatment weighting and Cox proportional hazards regression were utilized to estimate vaccine effectiveness (VE).</p><p><strong>Results: </strong>The study included 1,272,161 vaccinated individuals matched 1:1 with unvaccinated individuals, with a maximum follow-up of 128 (median 84) days. The VE against COVID-19 hospitalization was 51% (95% confidence interval [CI]: 48-54%). Subgroup analyses showed a VE of 56% (95% CI 51-61%) among adults ≥ 65 years and 46% (95% CI 39-52%) in immunocompromised adults. For medically attended COVID-19, the VE was 25% (95% CI 24-27%). Time-varying analyses showed that while VE declined over time, VE remained significant.</p><p><strong>Conclusion: </strong>During the 2023-2024 respiratory season, the mRNA-1273.815 vaccine significantly protected against COVID-19-related hospitalizations and medically attended COVID-19 across diverse adult populations and demonstrated durability of the effect. 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引用次数: 0
摘要
2023年9月，美国食品和药物管理局（FDA）批准了一种针对XBB.1.5亚谱系的最新mRNA COVID-19疫苗。本研究评估mRNA-1273.815（含2023-2024 Omicron xbb .1.5 mRNA- COVID-19疫苗）在预防美国≥18岁成人COVID-19相关住院和就医的有效性。方法：这项观察性、匹配队列研究使用了来自HealthVerity的医疗和药房索赔数据。在2023年9月12日至2023年12月31日期间接种mRNA-1273.815疫苗的成年人，随访至2024年1月26日。接种疫苗的个体与未接种任何2023-2024年COVID-19疫苗的个体在人口学和临床特征上进行匹配。主要结局和次要结局分别是COVID-19住院和就医COVID-19。利用治疗加权逆概率和Cox比例风险回归估计疫苗有效性（VE）。结果：该研究包括1,272,161名接种疫苗的个体与未接种疫苗的个体1:1匹配，最长随访时间为128天（中位84天）。COVID-19住院的VE为51%（95%可信区间[CI]: 48-54%）。亚组分析显示，≥65岁成人的VE为56% (95% CI 51-61%)，免疫功能低下成人的VE为46% （95% CI 39-52%）。对于就医的COVID-19， VE为25% （95% CI 24-27%）。时变分析表明，尽管VE随着时间的推移而下降，但VE仍然显著。结论：在2023-2024呼吸季节，mRNA-1273.815疫苗在不同成年人群中对COVID-19相关住院和就医的COVID-19有显著的保护作用，并表现出效果的持久性。这些结果支持继续使用最新的COVID-19疫苗，以减轻严重后果并维护公共卫生安全。
Evaluating the Effectiveness of mRNA-1273.815 Against COVID-19 Hospitalization Among Adults Aged ≥ 18 Years in the United States.
Introduction: In September 2023 the Food and Drug Administration (FDA) approved an updated mRNA COVID-19 vaccine targeting the XBB.1.5 sublineage. This study evaluates the effectiveness of mRNA-1273.815, a 2023-2024 Omicron XBB.1.5-containing mRNA COVID-19 vaccine in preventing COVID-19-related hospitalizations and medically attended COVID-19 in US adults aged ≥ 18 years.
Methods: This observational, matched cohort study used medical and pharmacy claims data from HealthVerity. Adults vaccinated with mRNA-1273.815 between September 12, 2023, and December 31, 2023, were followed through January 26, 2024. Vaccinated individuals were matched with individuals unvaccinated with any 2023-2024 COVID-19 vaccine on demographic and clinical characteristics. The primary and secondary outcomes were COVID-19 hospitalization and medically attended COVID-19, respectively. Inverse probability of treatment weighting and Cox proportional hazards regression were utilized to estimate vaccine effectiveness (VE).
Results: The study included 1,272,161 vaccinated individuals matched 1:1 with unvaccinated individuals, with a maximum follow-up of 128 (median 84) days. The VE against COVID-19 hospitalization was 51% (95% confidence interval [CI]: 48-54%). Subgroup analyses showed a VE of 56% (95% CI 51-61%) among adults ≥ 65 years and 46% (95% CI 39-52%) in immunocompromised adults. For medically attended COVID-19, the VE was 25% (95% CI 24-27%). Time-varying analyses showed that while VE declined over time, VE remained significant.
Conclusion: During the 2023-2024 respiratory season, the mRNA-1273.815 vaccine significantly protected against COVID-19-related hospitalizations and medically attended COVID-19 across diverse adult populations and demonstrated durability of the effect. These results support the continued use of updated COVID-19 vaccines to mitigate severe outcomes and maintain public health safety.
期刊介绍：
Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.
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