抗生素在儿童和青少年牙源性面部肿胀治疗中的应用：范围综述。

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-02-01 DOI:10.1016/j.jdent.2024.105523

Rachelle Welti , Dharini Ravindra , Leanne Teoh , Alastair Sloan , David Burgner , Mihiri Silva

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引用次数: 0

摘要

目的：确定在儿童和青少年牙源性面部肿胀治疗中使用抗生素的证据和指南。数据：纳入了0-16岁儿童和青少年牙源性面部肿胀的相关文章。排除了儿童数据无法与成人数据区分或参与者年龄未知的文章。同样被排除的还有那些没有提供针对特定年龄的建议的指南。排除了专门关注局部牙源性感染、路德维希心绞痛、颈部感染、眶蜂窝组织炎和败血症的资源，以及与牙源性面部肿胀和其他医学或牙科疾病相关的汇总数据的资源。资料来源：检索MEDLINE， PubMed和EMBASE，没有日期限制。谷歌高级检索用于识别灰色文献。研究选择：在5251篇确定的文章中，在全文审查后纳入了22项主要研究和32项次要证据来源。没有文章评估用于支持抗生素处方的特定诊断标准的使用。三项研究评估了抗生素治疗年轻人牙源性面部肿胀的有效性。抗生素治疗方案各不相同；口服阿莫西林是最常推荐的一线治疗，其次是苯氧甲基青霉素。大多数文章推荐抗生素作为牙科治疗的辅助手段。据报道，儿童体重、青霉素过敏/超敏反应和临床对治疗的反应通常会影响抗生素处方。确定了指南之间的不一致，这可能是由于缺乏关于在儿科人群中使用抗生素的证据。结论：对于患有牙源性面部肿胀的儿童和青少年，需要高质量、强有力的研究、明确定义的结果测量和全面的报告来制定全面的、基于证据的指南。临床相关性：本文允许临床医生比较指南建议，了解这些指南的背景和审查当地的做法。

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The use of antibiotics in the management of odontogenic facial swellings in children and adolescents: A scoping review

Objectives

To identify evidence and guidelines relating to the use of antibiotics in the management of odontogenic facial swellings in children and adolescents.

Data

Articles relating to odontogenic facial swellings in children and adolescents aged 0–16 years were included. Articles in which paediatric data could not be differentiated from adult data or where the age of participants were unknown were excluded. Also excluded were guidelines that did not provide age-specific recommendations. Resources that exclusively focused on localised odontogenic infections, Ludwig's Angina, neck infections, orbital cellulitis and sepsis and those that pooled data related to odontogenic facial swelling and other medical or dental conditions were excluded.

Sources

MEDLINE, PubMed and EMBASE were searched with no date restrictions. Google Advanced Search was used to identify grey literature.

Study selection

Of the 5251 identified articles, 22 primary studies and 32 secondary sources of evidence were included after full text review. No articles evaluated the use of specific diagnostic criteria used to support antibiotic prescribing. Three studies evaluated the effectiveness of antibiotic regimes in the management of odontogenic facial swellings in young people. Antibiotic regimes varied; oral amoxicillin was the most frequently recommended first-line therapy, followed by phenoxymethylpenicillin. Most articles recommended antibiotics as an adjunct to dental treatment. The weight of the child, penicillin allergy/ hypersensitivity and clinical response to therapy were commonly reported to influence antibiotic prescribing. Inconsistencies between guidelines were identified which is likely due to a lack of evidence regarding the use of antibiotics in the paediatric population.

Conclusions

High quality, robust research with clearly defined outcome measures and thorough reporting is required to develop comprehensive, evidence-based guidelines for children and adolescents with odontogenic facial swellings.

Clinical relevance

This paper allows clinicians to compare guideline recommendations, understand the context of these guidelines and review local practices.

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.