比较ADA和IDF在SHiDS研究中诊断中度高血糖和糖尿病的标准。

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI:10.1016/j.diabres.2024.111963

Yinan Zhang , Shuang Liu , Baige Cao , Jinfang Xu , Weiping Jia , Congrong Wang

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引用次数: 0

摘要

目的：本研究旨在根据美国糖尿病协会（ADA）和最近出版的国际糖尿病联合会（IDF）指南建立的诊断标准，评估IH和糖尿病的患病率，以及胰岛素分泌、胰岛素敏感性和不同糖耐量类别受试者的相关曲线模式。方法：我们使用来自上海高危糖尿病筛查（SHiDS）研究的5387名成年参与者的数据。所有参与者都进行了5分75 g口服葡萄糖耐量试验（OGTT）。然后根据ADA/IDF诊断标准对血糖状态进行分类，同时使用ogtt衍生指标评估胰岛素分泌和敏感性。结果：总体而言，3729名受试者被诊断符合ADA/IDF标准；941名和717名受试者在糖尿病和IH的诊断分类上分别表现出不一致。值得注意的是，与NGT/NGT组相比，所有这些诊断有差异的个体都表现出β细胞功能障碍和/或胰岛素抵抗。结论：ADA标准可识别1小时血糖（1小时PG）在正常范围内时血红蛋白a1c （HbA1c）水平升高的个体，而IDF标准可识别空腹血糖（FPG）、2小时血糖（2小时PG）和HbA1c在正常范围内时胰岛素敏感性和分泌受损的个体。

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查看原文本刊更多论文

Comparing ADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes in the SHiDS study

Aims

This study aimed to assess the prevalence of IH and diabetes, as well as insulin secretion, insulin sensitivity, and related curve patterns in subjects with different glucose tolerance categories according to the diagnostic criteria established by the American Diabetes Association (ADA) and the more recently published International Diabetes Federation (IDF) guidelines.

Methods

We used data of 5,387 adult participants from the Shanghai High-risk Diabetic Screen (SHiDS) study. All participants underwent a five-point 75 g oral glucose tolerance test (OGTT). Glycemic states were then classified according to the ADA/IDF diagnostic criteria, while OGTT-derived indices were employed to evaluate insulin secretion and sensitivity.

Results

Overall, 3,729 subjects were diagnosed consistently under ADA/IDF criteria; while 941 and 717 subjects exhibited inconsistencies in the diagnostic classification for diabetes and IH, respectively. Notably, all of these individuals with discrepant diagnoses displayed β-cell dysfunction and/or insulin resistance compared to the NGT/NGT group.

Conclusions

The ADA criteria can identify individuals with elevated haemoglobinA1c (HbA1c) levels when the 1-hour plasma glucose (1-h PG) stay within the normal range, while the IDF criteria can identify subjects with impaired insulin sensitivity and secretion when fasting plasma glucose (FPG), 2-hour plasma glucose (2-h PG) and HbA1c values are in the normal range.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.