{"title":"一种集成的可穿戴微流体生物传感器，用于同时检测汗液中的多种生物标志物。","authors":"Yong Zhang, Xin Zeng, Cuncun Wang, Yiyi Liu, Changpeng Jin, Jian Chen, Jingzhou Hou, Danqun Huo, Changjun Hou","doi":"10.1016/j.talanta.2024.127404","DOIUrl":null,"url":null,"abstract":"<p><p>Simultaneous detection of biomarkers in sweat is crucial for comprehensive health assessment and personalized monitoring. However, the low sweat secretion rate and low metabolite concentrations present challenges for developing non-invasive wearable sensors. This study aims to develop a flexible wearable biosensor for simultaneous detection of low-concentration biomarkers in sweat, enabling comprehensive health assessment. This study synthesized an innovative bimetallic tungstate Ag@Ag<sub>2</sub>WO<sub>4</sub> and evaluated its performance for detecting uric acid (UA, 10-1000 μM), dopamine (DA, 3-500 μM), and tyrosine (Tyr, 5-1000 μM). The detection limits (LODs) for DA, UA, and Tyr sensors were 3.10 μM, 8.47 μM, and 4.17 μM, respectively, with relative standard deviations (RSDs) of 4.76 %, 2.66 %, and 3.51 %, respectively. Additionally, this study designed a hydrophilic microfluidic collection system inspired by bamboo leaf structures to enhance sweat collection efficiency. Validation studies demonstrated that the wearable biosensor effectively detects UA and TA in the sweat of volunteers. We believe this research could contribute to advancing personalized healthcare by improving the convenience and effectiveness of health monitoring technologies.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127404"},"PeriodicalIF":5.6000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An integrated wearable microfluidic biosensor for simultaneous detection of multiple biomarkers in sweat.\",\"authors\":\"Yong Zhang, Xin Zeng, Cuncun Wang, Yiyi Liu, Changpeng Jin, Jian Chen, Jingzhou Hou, Danqun Huo, Changjun Hou\",\"doi\":\"10.1016/j.talanta.2024.127404\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Simultaneous detection of biomarkers in sweat is crucial for comprehensive health assessment and personalized monitoring. However, the low sweat secretion rate and low metabolite concentrations present challenges for developing non-invasive wearable sensors. This study aims to develop a flexible wearable biosensor for simultaneous detection of low-concentration biomarkers in sweat, enabling comprehensive health assessment. This study synthesized an innovative bimetallic tungstate Ag@Ag<sub>2</sub>WO<sub>4</sub> and evaluated its performance for detecting uric acid (UA, 10-1000 μM), dopamine (DA, 3-500 μM), and tyrosine (Tyr, 5-1000 μM). The detection limits (LODs) for DA, UA, and Tyr sensors were 3.10 μM, 8.47 μM, and 4.17 μM, respectively, with relative standard deviations (RSDs) of 4.76 %, 2.66 %, and 3.51 %, respectively. Additionally, this study designed a hydrophilic microfluidic collection system inspired by bamboo leaf structures to enhance sweat collection efficiency. Validation studies demonstrated that the wearable biosensor effectively detects UA and TA in the sweat of volunteers. We believe this research could contribute to advancing personalized healthcare by improving the convenience and effectiveness of health monitoring technologies.</p>\",\"PeriodicalId\":435,\"journal\":{\"name\":\"Talanta\",\"volume\":\"285 \",\"pages\":\"127404\"},\"PeriodicalIF\":5.6000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Talanta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.talanta.2024.127404\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Talanta","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.talanta.2024.127404","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/16 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
An integrated wearable microfluidic biosensor for simultaneous detection of multiple biomarkers in sweat.
Simultaneous detection of biomarkers in sweat is crucial for comprehensive health assessment and personalized monitoring. However, the low sweat secretion rate and low metabolite concentrations present challenges for developing non-invasive wearable sensors. This study aims to develop a flexible wearable biosensor for simultaneous detection of low-concentration biomarkers in sweat, enabling comprehensive health assessment. This study synthesized an innovative bimetallic tungstate Ag@Ag2WO4 and evaluated its performance for detecting uric acid (UA, 10-1000 μM), dopamine (DA, 3-500 μM), and tyrosine (Tyr, 5-1000 μM). The detection limits (LODs) for DA, UA, and Tyr sensors were 3.10 μM, 8.47 μM, and 4.17 μM, respectively, with relative standard deviations (RSDs) of 4.76 %, 2.66 %, and 3.51 %, respectively. Additionally, this study designed a hydrophilic microfluidic collection system inspired by bamboo leaf structures to enhance sweat collection efficiency. Validation studies demonstrated that the wearable biosensor effectively detects UA and TA in the sweat of volunteers. We believe this research could contribute to advancing personalized healthcare by improving the convenience and effectiveness of health monitoring technologies.
期刊介绍：
Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome.
Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.
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