免疫抑制硬脑膜源性巨噬细胞在小脑膜转移中的作用

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-12-20 DOI:10.1038/s43018-024-00859-1

Michael Kilian, Francisco J. Quintana

引用次数: 0

摘要

实体瘤的轻脑膜转移与预后差、治疗选择有限和免疫监测机制不明确有关。硬脑膜来源的免疫抑制巨噬细胞现在被证明可以迁移到脑脊液中，在脑膜轻脑膜转移模型中限制抗肿瘤CD8+ T细胞反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Immunosuppressive dura-derived macrophages in leptomeningeal metastasis

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Immunosuppressive dura-derived macrophages in leptomeningeal metastasis

Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are now shown to migrate to the cerebrospinal fluid, limiting anti-tumor CD8+ T cell responses in models of leptomeningeal metastasis.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.