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IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2024-09-30 DOI:10.1002/aoc.7775

Weiyan Chen, Jinxi Liu, Yingyu Zhan, Minghui Gao, Baohua Zhang

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引用次数: 0

摘要

ZIF-8 的合成主要使用六水硝酸锌（Zn(NO3)2.6H2O）作为锌源。Zn (NO3)2.6H2O易燃、易爆、腐蚀性强，对人体健康构成威胁。此外，2-甲基咪唑与锌源的摩尔比需要大于 20，导致成本增加。本研究利用绿色锌源（硫酸锌和醋酸锌），基于金属有机框架（ZIF-8）制备了一种 pH 值敏感的杀菌剂控释纳米胶囊 ZIF-8@Boscalid，具有更高的抗真菌效果和更低的生物毒性。负载率高达 34%。此外，由于 ZIF 结构中的弱酸性基团，杀菌剂 Boscalid 的释放表现出 pH 敏感性，在酸性条件下释放速度更快（< 5）。ZIF-8(A)@Boscalid 系统和 ZIF-8(S)@Boscalid 系统的累积释放率分别为 76.15% 和 86.22%。同时，当浓度为 300 mg/L 时，ZIF-8@啶酰菌胺对 CI-8 的抗真菌效果是市售产品的 1.5 倍；ZIF-8(A)@啶酰菌胺体系和 ZIF-8(S)@啶酰菌胺体系对 CJ-8 的抗菌活性值分别为 84.54% 和 78.65%。此外，采用本文所述方法获得的 ZIF-8@Boscalid 体系还具有一定的抗紫外线能力。因此，这项工作不仅证明了 ZIF-8@Boscalid 可作为纳米颗粒平台对 CJ-8 进行智能控制，而且还具有有效利用 Boscalid 并实现持续释放的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Facile and Safe Route to Fabricate Boscalid-Loaded ZIF-8 Nanoparticles With Efficient Antibacterial Activity and Long-Sustained Release

Synthesis of ZIF-8 mainly uses zinc nitrate hexahydrate (Zn(NO₃)₂.6H₂O) as the zinc source. Zn (NO₃)₂.6H₂O is flammable, explosive, and highly corrosive, posing a threat to human health. It also requires a molar ratio of 2-methylimidazole to zinc source greater than 20, resulting in increased costs. In this work, a pH-sensitive controlled-release nano-capsule of fungicide, ZIF-8@Boscalid, was established using green zinc sources (zinc sulfate and zinc acetate) and was prepared based on metal–organic framework (ZIF-8) for higher antifungal effect and low bio-toxicity. The loading ratio is as high as 34%. In addition, the release of fungicide Boscalid showed pH-sensitive response due to the weak acidic group in the ZIF structure, in which the rate of release was more rapid under acid condition (< 5). Cumulative release rates of the ZIF-8(A)@Boscalid system and ZIF-8(S)@Boscalid system were 76.15% and 86.22%, respectively. Meanwhile, the antifungal effect of ZIF-8@Boscalid was 1.5 times more of that commercially available product on CI-8 at the concentration of 300 mg/L, and the antibacterial activity values of the ZIF-8(A)@Boscalid system and ZIF-8(S)@Boscalid system against CJ-8 were 84.54% and 78.65%, respectively. Furthermore, the obtained ZIF-8@Boscalid system using the method described in this article exhibited certain UV resistance. Thus, this work not only proves that ZIF-8@Boscalid could be used as nanoparticles platform for smart control over CJ-8 but also has great potential effective utilization of Boscalid and achieving sustained release.

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.