用于骨髓炎治疗的多功能镁合金支架：集耐腐蚀、成骨活性和抗菌作用于一体

IF 13.2 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2024-12-20 DOI:10.1016/j.cej.2024.158712

Chaoxin Wang, Yutian Luo, Yunong Shen, Bingchuan Liu, Zhengguang Wang, Caimei Wang, Xiaolin Ma, Peng Wen, Yufeng Zheng, Yun Tian

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引用次数: 0

摘要

我们将等离子体浸没离子注入（PIII）和高温氧化处理（HTO）同时应用于生物可降解镁合金，以减少镁合金基体的腐蚀，同时提高其成骨性能和抗菌性能。HTO处理后的可生物降解镁合金进行离子注入。然后，我们评估了HTO&；PIII支架作为可生物降解材料的生物相容性、成骨性能和抗菌性能。HTO&；PIII支架的体外和体内抗菌性能和治疗效果证明了其有效性。这些结果提示HTO&；PIII支架在骨髓炎治疗中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Multifunctional magnesium alloy scaffolds for osteomyelitis therapy: Integrating corrosion resistance, osteogenic activity, and antibacterial effects

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Multifunctional magnesium alloy scaffolds for osteomyelitis therapy: Integrating corrosion resistance, osteogenic activity, and antibacterial effects

We simultaneously applied plasma immersion ion implantation (PIII) and high-temperature oxidation treatment (HTO) to biodegradable magnesium alloys to reduce corrosion of the magnesium alloy matrix while increasing their osteogenic performance and antibacterial capability. After HTO treatment, the biodegradable magnesium alloy underwent ion implantation. We then evaluated the biocompatibility, osteogenic performance, and antibacterial properties of the HTO&PIII scaffold as a biodegradable material. The in vitro and in vivo antibacterial performance and therapeutic efficacy of the HTO&PIII scaffold demonstrated its effectiveness. These results suggest the potential application of the HTO&PIII scaffold in the treatment of osteomyelitis.

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来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.