LEDGF/p75 （PSIP1）在肿瘤发生中的作用分子机制和治疗潜力的见解。

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-01 DOI:10.1016/j.bbcan.2024.189248

Muluembet Akele , Matteo Iervolino , Siska Van Belle , Frauke Christ , Zeger Debyser

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引用次数: 0

摘要

由于参与转录调节的蛋白质功能障碍导致的基因异常表达是肿瘤发展的一个标志。事实上，靶向转录调节因子代表了癌症治疗中的一种新兴方法。晶状体上皮源性生长因子（LEDGF/p75, PSIP1）是一种共转录激活因子，可将几种蛋白质拴在染色质上。LEDGF/p75与HIV感染和mll重排白血病等疾病有关。值得注意的是，LEDGF/p75在包括前列腺癌和乳腺癌在内的多种人类癌症中上调。在这篇综述中，我们讨论了LEDGF/p75在不同恶性肿瘤中的重要作用，并探讨了其在肿瘤发生中的机制贡献，揭示了其作为化疗治疗靶点的潜力。

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Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential

Aberrant gene expression due to dysfunction in proteins involved in transcriptional regulation is a hallmark of tumor development. Indeed, targeting transcriptional regulators represents an emerging approach in cancer therapeutics. Lens epithelium-derived growth factor (LEDGF/p75, PSIP1) is a co-transcriptional activator that tethers several proteins to the chromatin. LEDGF/p75 has been implicated in diseases such as HIV infection and KMT2A-rearranged leukemia. Notably, LEDGF/p75 is upregulated in various human cancers including prostate and breast cancer. In this review, we discuss the essential role of LEDGF/p75 in different malignancies and explore its mechanistic contribution to tumorigenesis revealing its potential as a therapeutic target for chemotherapy.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.