步态冻结塑造帕金森病患者的姿势控制：视觉信息和药物状态的影响。
IF 1.4
3区 医学
Q4 ENGINEERING, BIOMEDICAL
引用次数: 0
摘要
背景：压力中心的几种测量方法已被用于描述帕金森病（PD）患者体位摇摆的大小和结构。本研究旨在探讨压力轨迹中心的大小和结构是否可以区分PD患者在开药和停药状态下以及睁眼和闭眼状态下步态是否冻结。方法：对24例PD患者（无步态冻结者14例，步态冻结者10例）进行分析。参与者尽可能静止地站在一个测力板上30秒，眼睛睁着或闭着，开着或停着。采用方差分析检验各组、用药状态和视觉信息对压力椭圆中心的大小（面积）和结构（以轴长与方向之比测量形状）的影响。结果：在服药状态和步态冻结的PD中，压力椭圆中心比步态未冻结的PD要短。此外，仅在服药状态下，冻结步态的PD的椭圆幅度大于未冻结步态的PD。在相同条件下，冷冻状态下、服药状态下、闭眼状态下PD患者的椭圆方向比未冷冻状态下PD患者的椭圆方向更斜。解释：根据药物状态和视觉信息的可用性，PD患者步态冻结和不冻结的姿势摇摆的大小和结构不同。本文章由计算机程序翻译，如有差异，请以英文原文为准。
Freezing of gait shapes the postural control of individuals with Parkinson's disease: Effect of visual information and medication states
Background
Several measures of the center of pressure have been used to describe magnitude and structure of the postural sway in individuals with Parkinson's disease (PD). This study aimed to examine whether both the magnitude and structure of the center of pressure trajectory can differentiate PD individuals with and without freezing of gait in both On- and Off-medication states and with eyes open and closed.
Methods
Twenty-four individuals with PD (14 without and 10 with freezing of gait) were tested. Participants stood as still as possible on a force plate for 30 s with eyes open and closed and On- and Off-medication. Analyses of variance were used to test the effect of group, medication state, and visual information on the magnitude (area) and structure (shape measured by the ratio between axes length and orientation) of the center of pressure ellipses.
Findings
The center of pressure ellipses were less elongated in On-medication state and for PD with freezing of gait than without freezing of gait. Moreover, the magnitude of the ellipses was larger for PD with freezing than without freezing of gait only in the On-medication state. The orientation of the ellipses was more diagonal for individuals with freezing, in the On-medication state, and with the eyes closed when compared to individuals with PD without freezing under the same conditions.
Interpretation
Magnitude and structure of the postural sway differed between PD individuals with and without freezing of gait, depending on the medication state and the availability of the visual information.
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来源期刊
Clinical Biomechanics
医学-工程：生物医学
CiteScore
3.30
自引率
5.60%
发文量
189
审稿时长
12.3 weeks
期刊介绍：
Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field.
The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management.
A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly.
Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians.
The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time.
Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.
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