法洛氏四联症修复后的心脏磁共振成像:纵向中期随访研究。

IF 2.6 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
PLoS ONE Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.1371/journal.pone.0308362
Golnaz Houshmand, Rahem Rahmati, Elahe Meftah, Fatemeh Zarimeidani, Mohammadrafi Khorgami, Seyyed Mojtaba Ghorashi, Amir Fazeli, Negar Omidi, Sedigheh Saedi, Marzieh Motevalli, Majid Maleki, Hamidreza Pouraliakbar
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引用次数: 0

摘要

背景:双心室功能障碍在修复的法洛四联症患者中很常见,需要常规影像学监测病情恶化,并确定是否需要进行肺瓣膜置换术(PVR)等手术。本研究旨在强调心脏磁共振成像(CMR)参数及其与这些患者中期随访不良结局的关系。方法:本纵向研究招募了2007年至2017年在Rajaie中心至少间隔三个月进行两次CMR成像的所有法洛四联症(TFTC)病史患者。结果:56例TFTC患者平均年龄15.23±11.66岁,性别比例为1:1。对于不良事件,18例(32%)患者进行了PVR。右、左心室功能障碍分别为43例(76.8%)和18例(32.1%)。在本研究中未发生死亡。47例(92.2%)出现RVOT纤维化。结论:心肌应变和心室-动脉耦合参数可以强调个性化的治疗方法和随访,以改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cardiac magnetic resonance imaging in repaired tetralogy of Fallot: A longitudinal midterm follow-up study.

Cardiac magnetic resonance imaging in repaired tetralogy of Fallot: A longitudinal midterm follow-up study.

Cardiac magnetic resonance imaging in repaired tetralogy of Fallot: A longitudinal midterm follow-up study.

Cardiac magnetic resonance imaging in repaired tetralogy of Fallot: A longitudinal midterm follow-up study.

Background: Biventricular dysfunction is frequent in patients with repaired tetralogy of Fallot, necessitating routine imaging to monitor for worsening conditions and determine whether procedures like pulmonary valve replacement (PVR) are needed. This study aimed to highlight the parameters of cardiac magnetic resonance imaging (CMR) and their association with adverse outcomes in the midterm follow-up of these patients.

Methods: This longitudinal study recruited all patients with a history of tetralogy of Fallot total correction (TFTC) who had two CMR images at a minimum three-month interval at Rajaie Center from 2007 through 2017.

Results: Fifty-six patients at a mean age of 15.23 ± 11.66 years at TFTC and a 1:1 gender distribution were assessed. Regarding adverse events, PVR was done on 18 patients (32%). Right and left ventricular dysfunction occurred in 43 (76.8%) and 18 (32.1%) patients, respectively. Death did not occur in the present study. RVOT fibrosis was present in 47 (92.2%). The stroke volume of both ventricles increased during the follow-up (P <0.05), although end-diastolic volume indices, end-systolic volume indices, ejection fractions, strain parameters, and ventriculoarterial coupling did not change significantly. Patients requiring PVR had a significantly higher end-systolic volume index in both ventricles (P <0.05) and a lower right-sided ejection fraction (P <0.01) and coupling ratio (P <0.05). The ejection fraction in the left ventricle correlated with global circumferential strain (P <0.01), while in the right ventricle, it correlated with global longitudinal strain (P <0.05) and the right-sided coupling ratio (P <0.01).

Conclusion: Myocardial strain and ventriculoarterial coupling parameters could underscore personalized-approached therapy and follow-up to improve outcomes.

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来源期刊
PLoS ONE
PLoS ONE 生物-生物学
CiteScore
6.20
自引率
5.40%
发文量
14242
审稿时长
3.7 months
期刊介绍: PLOS ONE is an international, peer-reviewed, open-access, online publication. PLOS ONE welcomes reports on primary research from any scientific discipline. It provides: * Open-access—freely accessible online, authors retain copyright * Fast publication times * Peer review by expert, practicing researchers * Post-publication tools to indicate quality and impact * Community-based dialogue on articles * Worldwide media coverage
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