Zhaoying Chen, Chenxi Zhang, Chunfeng Meng, Yadan Hu, Yazhuo Niu, Bingrui Gao, Jinshuo Wang, Lu Liu, Kan Chen, Zhongyan Shan, Weiping Teng, Jing Li
{"title":"揭示联系：抗蛋白二硫异构酶A3自身抗体表达和多囊卵巢综合征的风险在甲状腺自身免疫性甲状腺炎妇女。","authors":"Zhaoying Chen, Chenxi Zhang, Chunfeng Meng, Yadan Hu, Yazhuo Niu, Bingrui Gao, Jinshuo Wang, Lu Liu, Kan Chen, Zhongyan Shan, Weiping Teng, Jing Li","doi":"10.1186/s13048-024-01569-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common complication of autoimmune thyroiditis (AIT) in women, but the underlying mechanism remains unclear. Protein disulfide isomerase A3 (PDIA3) is a ubiquitous protein. We have reported that PDIA3 autoantibody (PDIA3Ab) production results from autoimmune responses against thyrocytes, resulting in its high expression in euthyroid AIT patients. This study aimed to explore potential correlations between PDIA3Ab expression and concurrent PCOS in euthyroid AIT women.</p><p><strong>Methods: </strong>This is a single-center cross-sectional study. All participants, who visited the First Hospital of China Medical University from April 2023 to May 2024, were assigned to four groups according to AIT and PCOS diagnostic criteria. The PDIA3Ab levels of total IgG and IgG subclasses were detected using ELISA.</p><p><strong>Results: </strong>From highest to lowest, PDIA3Ab total serum IgG levels were categorized as follows: AIT-PCOS group > AIT-non-PCOS group > non-AIT-PCOS group > non-AIT-non-PCOS group Significant differences were observed between each pair of groups, except for the non-AIT-PCOS and non-AIT-non-PCOS groups. Further analysis of the subclasses of PDIA3Ab revealed that serum IgG1 levels in the AIT-PCOS and AIT-non-PCOS groups were significantly higher than those in the non-AIT-PCOS and non-AIT-non-PCOS groups. In addition, the AIT-PCOS group had significantly higher serum IgG3 levels than the other three groups. Binary logistic regression analysis revealed that the PDIA3Ab total IgG level was an independent risk factor for concurrent PCOS in euthyroid AIT women (Q4 vs. Q1: OR, 95%CI = 5.082, 1.348-19.16). Furthermore, a trend test demonstrated a titer-dependent increase in PCOS prevalence among AIT women as the PDIA3Ab total IgG level increased.</p><p><strong>Conclusions: </strong>The expression of serum PDIA3Ab may indicate an increased risk of PCOS in euthyroid AIT women and could potentially serve as new targets for markers or immune intervention.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"17 1","pages":"247"},"PeriodicalIF":3.8000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656784/pdf/","citationCount":"0","resultStr":"{\"title\":\"Unveiling the link: anti-protein disulfide isomerase A3 autoantibody expression and polycystic ovary syndrome risk in euthyroid autoimmune thyroiditis women.\",\"authors\":\"Zhaoying Chen, Chenxi Zhang, Chunfeng Meng, Yadan Hu, Yazhuo Niu, Bingrui Gao, Jinshuo Wang, Lu Liu, Kan Chen, Zhongyan Shan, Weiping Teng, Jing Li\",\"doi\":\"10.1186/s13048-024-01569-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common complication of autoimmune thyroiditis (AIT) in women, but the underlying mechanism remains unclear. Protein disulfide isomerase A3 (PDIA3) is a ubiquitous protein. We have reported that PDIA3 autoantibody (PDIA3Ab) production results from autoimmune responses against thyrocytes, resulting in its high expression in euthyroid AIT patients. This study aimed to explore potential correlations between PDIA3Ab expression and concurrent PCOS in euthyroid AIT women.</p><p><strong>Methods: </strong>This is a single-center cross-sectional study. All participants, who visited the First Hospital of China Medical University from April 2023 to May 2024, were assigned to four groups according to AIT and PCOS diagnostic criteria. The PDIA3Ab levels of total IgG and IgG subclasses were detected using ELISA.</p><p><strong>Results: </strong>From highest to lowest, PDIA3Ab total serum IgG levels were categorized as follows: AIT-PCOS group > AIT-non-PCOS group > non-AIT-PCOS group > non-AIT-non-PCOS group Significant differences were observed between each pair of groups, except for the non-AIT-PCOS and non-AIT-non-PCOS groups. Further analysis of the subclasses of PDIA3Ab revealed that serum IgG1 levels in the AIT-PCOS and AIT-non-PCOS groups were significantly higher than those in the non-AIT-PCOS and non-AIT-non-PCOS groups. In addition, the AIT-PCOS group had significantly higher serum IgG3 levels than the other three groups. Binary logistic regression analysis revealed that the PDIA3Ab total IgG level was an independent risk factor for concurrent PCOS in euthyroid AIT women (Q4 vs. Q1: OR, 95%CI = 5.082, 1.348-19.16). 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引用次数: 0
摘要
背景：多囊卵巢综合征（PCOS）是女性自身免疫性甲状腺炎（AIT）的常见并发症，但其潜在机制尚不清楚。蛋白质二硫异构酶A3 （PDIA3）是一种普遍存在的蛋白质。我们报道了PDIA3自身抗体（PDIA3Ab）的产生是由于对甲状腺细胞的自身免疫反应，导致其在甲状腺功能正常的AIT患者中高表达。本研究旨在探讨甲状腺功能正常的AIT女性PDIA3Ab表达与并发PCOS的潜在相关性。方法：这是一项单中心横断面研究。所有受试者于2023年4月至2024年5月在中国医科大学第一医院就诊，根据AIT和PCOS诊断标准分为四组。ELISA法检测总IgG和IgG亚类PDIA3Ab水平。结果：PDIA3Ab血清总IgG水平由高到低分为：AIT-PCOS组> ait -非pcos组>非AIT-PCOS组>非ait -非pcos组除非AIT-PCOS组和非ait -非pcos组外，各组间差异均有统计学意义。进一步分析PDIA3Ab亚类发现，AIT-PCOS和ait -非pcos组血清IgG1水平显著高于非AIT-PCOS和非ait -非pcos组。此外，AIT-PCOS组血清IgG3水平明显高于其他三组。二元logistic回归分析显示，PDIA3Ab总IgG水平是甲状腺功能正常的AIT女性并发PCOS的独立危险因素（Q4 vs. Q1: OR, 95%CI = 5.082, 1.348-19.16）。此外，趋势测试表明，随着PDIA3Ab总IgG水平的升高，AIT女性PCOS患病率呈滴度依赖性增加。结论：血清PDIA3Ab的表达可能预示着甲状腺功能正常的AIT妇女PCOS的风险增加，可能作为标志物或免疫干预的新靶点。
Unveiling the link: anti-protein disulfide isomerase A3 autoantibody expression and polycystic ovary syndrome risk in euthyroid autoimmune thyroiditis women.
Background: Polycystic ovary syndrome (PCOS) is a common complication of autoimmune thyroiditis (AIT) in women, but the underlying mechanism remains unclear. Protein disulfide isomerase A3 (PDIA3) is a ubiquitous protein. We have reported that PDIA3 autoantibody (PDIA3Ab) production results from autoimmune responses against thyrocytes, resulting in its high expression in euthyroid AIT patients. This study aimed to explore potential correlations between PDIA3Ab expression and concurrent PCOS in euthyroid AIT women.
Methods: This is a single-center cross-sectional study. All participants, who visited the First Hospital of China Medical University from April 2023 to May 2024, were assigned to four groups according to AIT and PCOS diagnostic criteria. The PDIA3Ab levels of total IgG and IgG subclasses were detected using ELISA.
Results: From highest to lowest, PDIA3Ab total serum IgG levels were categorized as follows: AIT-PCOS group > AIT-non-PCOS group > non-AIT-PCOS group > non-AIT-non-PCOS group Significant differences were observed between each pair of groups, except for the non-AIT-PCOS and non-AIT-non-PCOS groups. Further analysis of the subclasses of PDIA3Ab revealed that serum IgG1 levels in the AIT-PCOS and AIT-non-PCOS groups were significantly higher than those in the non-AIT-PCOS and non-AIT-non-PCOS groups. In addition, the AIT-PCOS group had significantly higher serum IgG3 levels than the other three groups. Binary logistic regression analysis revealed that the PDIA3Ab total IgG level was an independent risk factor for concurrent PCOS in euthyroid AIT women (Q4 vs. Q1: OR, 95%CI = 5.082, 1.348-19.16). Furthermore, a trend test demonstrated a titer-dependent increase in PCOS prevalence among AIT women as the PDIA3Ab total IgG level increased.
Conclusions: The expression of serum PDIA3Ab may indicate an increased risk of PCOS in euthyroid AIT women and could potentially serve as new targets for markers or immune intervention.
期刊介绍：
Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ.
Topical areas include, but are not restricted to:
Ovary development, hormone secretion and regulation
Follicle growth and ovulation
Infertility and Polycystic ovarian syndrome
Regulation of pituitary and other biological functions by ovarian hormones
Ovarian cancer, its prevention, diagnosis and treatment
Drug development and screening
Role of stem cells in ovary development and function.
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