新生女儿通过PI(3,5) p2介导的空泡酸化获得新的开始。

IF 6.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-01-06 Epub Date: 2024-12-20 DOI:10.1083/jcb.202412054

Patricia M Kane

引用次数: 0

摘要

Huda等人（https://doi.org/10.1083/jcb.202406170）揭示了酵母子细胞溶酶体样液泡中PI(3,5)P2水平的短暂细胞周期依赖性增加。由此产生的脂质不对称改变了子细胞和母细胞的液泡pH值，并将影响多种下游功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Newborn daughters get a fresh start through PI(3,5)P2-mediated vacuolar acidification.

Huda et al. (https://doi.org/10.1083/jcb.202406170) reveal a transient, cell cycle-dependent increase in PI(3,5)P2 levels at the lysosome-like vacuole of yeast daughter cells. The resulting lipid asymmetry alters vacuolar pH in both daughter and mother cells and will impact multiple downstream functions.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.