大戟中具有抗炎活性的Ingenane二萜类化合物。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI:10.1016/j.fitote.2024.106350

Ren-Fen Ma, Qian Wu, Yin-Po Pan, Hu Liu, Xin-Cheng Zhuang, Hua Zhang

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引用次数: 0

摘要

大戟科植物以其具有多种结构和广泛生物活性的二萜类成分而闻名。本文介绍了从 Euphorbia antiquorum 中发现的 15 种 ingenane 二萜类化合物，包括 10 种以前未报道过的化合物（1-10）。通过详细的光谱分析，确定了这些未被描述的化合物的结构。同时，初步的抗炎筛选显示，化合物 6 在脂多糖刺激的 RAW264.7 巨噬细胞中对一氧化氮的产生具有显著的抑制活性，并能下调 COX-2 和 IL-6 的表达。进一步的机理研究发现，化合物 6 可以通过抑制 NF-κB 和激活 Nrf2 信号通路来发挥抗炎作用。

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Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum.

The Euphorbia plants are famous for their diterpenoid constituents with diverse structures and broad biological activities. Herein, the discovery of 15 ingenane diterpenoids including 10 previously unreported ones (1-10) from Euphorbia antiquorum was presented. Structures of the undescribed compounds were established via detailed spectroscopic analyses. Meanwhile, a preliminary anti-inflammatory screening revealed that compound 6 showed significant inhibitory activity against the production of nitric oxide, as well as downregulated the expression of COX-2 and IL-6, in lipopolysaccharide-stimulated RAW264.7 macrophages. Further mechanistical exploration revealed that compound 6 could exert its anti-inflammatory effect by inhibiting NF-κB and activating Nrf2 signaling pathways.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.