Sara Knigge, Günes Dogan, Ezin Deniz, Jasmin Hanke, Ali Merzah, Dominik Berliner, Fanwu Kong, Torsten Heilmann, Bastian Schmack, Aron F. Popov, Alexander Weymann, Johann Bauersachs, Arjang Ruhparwar, Jan D. Schmitto
{"title":"两个耦合连续血流心室辅助装置作为一种新型BIVAD与一个驱动急性动物研究结果。","authors":"Sara Knigge, Günes Dogan, Ezin Deniz, Jasmin Hanke, Ali Merzah, Dominik Berliner, Fanwu Kong, Torsten Heilmann, Bastian Schmack, Aron F. Popov, Alexander Weymann, Johann Bauersachs, Arjang Ruhparwar, Jan D. Schmitto","doi":"10.1111/aor.14933","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The study assesses the feasibility of the DuoCor BiVAS, a novel biventricular assist system integrating magnetic levitation technology.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In an acute large animal model involving five sheep, each received the DuoCor BiVAS without cardiopulmonary bypass. Hemodynamic and device parameters were monitored continuously for 1-h post-implantation.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Intraoperative implantation was uneventful, demonstrating successful biventricular support with mean blood flows of 5.4 LPM (left) and 5.5 LPM (right). Analysis showed proportional flow rates and relationships between pump speed, flow, and power consumption. No adverse events like thrombus formation, bleeding, stroke, or device failure occurred.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This research underscores the DuoCor BiVAS's potential for severe biventricular heart failure treatment, providing insights into its feasibility and functionality in acute animal models. The findings suggest promising clinical applications, particularly with the system's single driveline design potentially enhancing patient mobilization and quality of life. Further investigations are needed to advance this technology for broader clinical use.</p>\n </section>\n </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 3","pages":"525-531"},"PeriodicalIF":2.2000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.14933","citationCount":"0","resultStr":"{\"title\":\"Two Coupled Continuous-Flow Ventricular Assist Devices as a Novel BIVAD With One Driveline: Acute Animal Study Results\",\"authors\":\"Sara Knigge, Günes Dogan, Ezin Deniz, Jasmin Hanke, Ali Merzah, Dominik Berliner, Fanwu Kong, Torsten Heilmann, Bastian Schmack, Aron F. Popov, Alexander Weymann, Johann Bauersachs, Arjang Ruhparwar, Jan D. Schmitto\",\"doi\":\"10.1111/aor.14933\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The study assesses the feasibility of the DuoCor BiVAS, a novel biventricular assist system integrating magnetic levitation technology.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In an acute large animal model involving five sheep, each received the DuoCor BiVAS without cardiopulmonary bypass. Hemodynamic and device parameters were monitored continuously for 1-h post-implantation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Intraoperative implantation was uneventful, demonstrating successful biventricular support with mean blood flows of 5.4 LPM (left) and 5.5 LPM (right). Analysis showed proportional flow rates and relationships between pump speed, flow, and power consumption. 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Two Coupled Continuous-Flow Ventricular Assist Devices as a Novel BIVAD With One Driveline: Acute Animal Study Results
Background
The study assesses the feasibility of the DuoCor BiVAS, a novel biventricular assist system integrating magnetic levitation technology.
Methods
In an acute large animal model involving five sheep, each received the DuoCor BiVAS without cardiopulmonary bypass. Hemodynamic and device parameters were monitored continuously for 1-h post-implantation.
Results
Intraoperative implantation was uneventful, demonstrating successful biventricular support with mean blood flows of 5.4 LPM (left) and 5.5 LPM (right). Analysis showed proportional flow rates and relationships between pump speed, flow, and power consumption. No adverse events like thrombus formation, bleeding, stroke, or device failure occurred.
Conclusion
This research underscores the DuoCor BiVAS's potential for severe biventricular heart failure treatment, providing insights into its feasibility and functionality in acute animal models. The findings suggest promising clinical applications, particularly with the system's single driveline design potentially enhancing patient mobilization and quality of life. Further investigations are needed to advance this technology for broader clinical use.
期刊介绍：
Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.
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