有机光催化吲哚与硅烷的脱芳硅氢化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-12-17 DOI:10.1039/D4OB01792G

Qiao Zhang, Yadi Xu, Congjian Xia, Wengang Xu and Mingbo Wu

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引用次数: 0

摘要

在由 3DPA2FBN （2,4,6-三(二苯基氨基)-3,5-二氟苯腈）、(i-Pr)3SiSH 和碱添加剂组成的光氧化和氢原子转移催化体系的配合下，通过碳-硅自由基偶联过程，完成了吲哚衍生物与硅烷的光催化脱芳烃氢化反应，从而合成了有价值的吲哚啉基硅烷。该方法具有底物范围广、无过渡金属条件、非对映选择性高以及可应用于天然产物衍生物等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Organo-photocatalytic dearomative hydrosilylation of indoles with silanes†

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Organo-photocatalytic dearomative hydrosilylation of indoles with silanes†

A photocatalytic dearomative hydrosilylation reaction of indole derivatives with silanes has been accomplished for the synthesis of valuable indolinyl silanes through a carbon-silyl radical coupling process with the cooperation of photoredox and hydrogen atom transfer catalytic systems composed of 3DPA2FBN (2,4,6-tris(diphenylamino)-3,5-difluorobenzonitrile), (i-Pr)₃SiSH, and base additives. This protocol is featured by a broad substrate scope, transition metal-free conditions, high diastereoselectivities and applications in natural product derivatives.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.