Xiao-Xiao Chen, Kun Peng, Xi Chen, Zheng-Yin Pan, Qing-Hua Shen, Yu-Yi Ling, Jian-Zhang Zhao, Cai-Ping Tan
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Back Cover: Microtubule polymerization induced by iridium-fullerene photosensitizers for cancer immunotherapy via dual-reactive oxygen species regulation strategy
The constructive chemical combination of iridium(III) complexes and C60 moiety endows Ir-C601 with dual reactive oxygen species (ROS) regulation abilities and promising antitumor photo-immunotherapeutic activities. In the dark, Ir-C601 serves as ROS scavengers to reverse dysfunctional T cells. Upon photo irradiation, Ir-C601 can produce various ROS and oxidize tubulin to exert efficient photo-immunotherapeutic effects through multiple antitumor pathways (e623).
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