金鸡纳生物碱的位点选择性合成修饰

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2024-10-07 DOI:10.1002/ajoc.202400397

Finlay P. Player, Daniel J. Foley

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引用次数: 0

摘要

奎宁的天然产物为人类所知已有几个世纪，在那段时间里，奎宁在治疗疟疾方面发挥了关键作用。奎宁和相关金鸡纳生物碱在化学和生物学科中得到了广泛的应用，部分原因是其支架中含有过多的官能团和立体化学信息。本文综述了金鸡纳生物碱的选择性合成修饰。我们的比较分析可以作为金鸡纳生物碱选择性功能化的“用户手册”，旨在促进对金鸡纳化学中显着和鲜为人知的方面的考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Site-Selective Synthetic Modifications of the Cinchona Alkaloids

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Site-Selective Synthetic Modifications of the Cinchona Alkaloids

The natural product quinine has been known to humankind for centuries, and in that time has played a pivotal role in the treatment of malaria. Quinine, and the related cinchona alkaloids, have seen widespread contemporary use across chemical and biological disciplines, owing in part to the plethora of functional groups and stereochemical information contained within their scaffold. This review focuses on site-selective synthetic modifications of the cinchona alkaloids. Our comparative analysis may act as a ‘user manual’ for the selective functionalisation of the cinchona alkaloids, and aims to promote consideration of remarkable and lesser-understood aspects of cinchona chemistry.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.