氨基酸合成融合双环[1,2,4]-三唑

IF 3.6 2区 化学 Q1 CHEMISTRY, ORGANIC
Joyann S. Donaldson*, Matthew Del Bel, John Braganza, Sujin Cho-Schultz, Mingying He, Bryan Li, Congjun Liu, Jean Matthews, Sajiv K. Nair, Martha Ornelas, Feng Shi, Chengfu Xie, Qing Zhang and Ru Zhou, 
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引用次数: 0

摘要

3步模块化程序结合羧酸与酰基肼提供了获得医学相关的[1,2,4]-融合三唑。通过对脂肪族和芳基取代基以及5-、6-和7元环的耐受性,实现了良好到优异的产率。可以避免柱层析的条件,适用于小规模的发现工作以及大规模的开发过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Synthesis of Fused Bicyclic [1,2,4]-Triazoles from Amino Acids

Synthesis of Fused Bicyclic [1,2,4]-Triazoles from Amino Acids

A 3-step modular procedure combining carboxylic acids with acyl hydrazines provides access to medicinally relevant [1,2,4]-fused triazoles. Good to excellent yields are achieved with tolerance of aliphatic and aryl substituents as well as 5-, 6-, and 7-membered rings for the fused ring. Conditions that can avoid column chromatography and be applicable for both small scale discovery efforts as well as large scale development processes are demonstrated within.

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来源期刊
Journal of Organic Chemistry
Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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