基于芳香氨基酸天线的发光铽探针用于区分腺嘌呤和鸟嘌呤核苷酸

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-12-20 DOI:10.1039/d4cc05232c

Sunanda Pradhan , Nitin Shukla , Goutam Panigrahi , Ashis K. Patra

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引用次数: 0

摘要

在此，我们提出了一系列发光的Tb（III）探针（[Tb- ltp], [Tb- ltyr], [Tb- lphe]），用于检测和区分嘌呤核苷多磷酸（NPP），这些探针基于修饰的DTTA螯合剂附加在芳香氨基酸（Laa）上。光学上最有效的发光探针[Tb- ltp]在生物浓度范围内通过基于pet的Tb（III）发光调制优先区分鸟嘌呤- npps和腺嘌呤- npps。

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Luminescent terbium(iii) probes containing an aromatic amino acid-based antenna for discrimination between adenine and guanine nucleotides†

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Luminescent terbium(iii) probes containing an aromatic amino acid-based antenna for discrimination between adenine and guanine nucleotides†

Herein we present a series of luminescent Tb(iii)-probes ([], [], and []) for sensing and discriminating purine nucleoside polyphosphates (NPP) based on a modified DTTA chelator appended to aromatic amino acids (). The optically most effective luminescent [] probe preferentially discriminates the guanine-NPPs over the adenine-NPPs via PeT-based modulation of Tb(iii) luminescence within the biological concentration range.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.