短期口服亚硝酸盐可降低训练和久坐Wistar大鼠的动脉僵硬度。

Thiago Pereira Souza, Lidieli Pazin Tardelli, Rafael Antunes Nicoletti, André Mourão Jacomini, Gabriel Francisco de Mello Martins, Lucas Cézar Pinheiro, José Eduardo Tanus-Santos, Sandra Lia do Amaral, Anderson Saranz Zago
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引用次数: 0

摘要

背景:一氧化氮(NO)在血压(BP)调节中起重要作用,通过血管舒张直接作用于周围血管阻力。体育训练(通过eNOS/NO)和摄入亚硝酸盐被认为是增加NO的主要刺激因素。目的:观察口服亚硝酸盐和有氧运动训练对Wistar大鼠血压和动脉硬度的影响。方法:39只年轻雄性Wistar大鼠分为静养-对照组(SC)、静养-亚硝酸盐组(SN)、训练-对照组(TC)和训练-亚硝酸盐组(TN),每组9或10只。他们在跑步机上进行有氧体能训练,为期8周(体能的50-60%,每天1小时,每周5天)或久坐不动。在训练的最后6天,给予亚硝酸盐口服(15 mg/Kg灌胃)。在训练和口服亚硝酸盐给药期后,评估血压、动脉僵硬度、血浆和组织亚硝酸盐浓度。以p < 0.05为显著水平。结果:口服亚硝酸盐可有效降低动脉僵硬值(TN, -23%;SN -15%)。仅进行一种干预的两组患者的收缩压均低于对照组(TC vs SC, -14.23;SN vs SC, - 12.46)。结论:我们得出结论,短期口服6天和有氧体育训练计划可以促进雄性Wistar大鼠的血液动力学益处,如动脉硬度和血压的改善。这些反应表明,体育锻炼和补充亚硝酸钠可以作为预防和治疗高血压的替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-term Oral Nitrite Administration Decreases Arterial Stiffness in Both Trained and Sedentary Wistar Rats.

Background: Nitric Oxide (NO) plays an important role in blood pressure (BP) regulation, acting directly on peripheral vascular resistance through vasodilation. Physical training (via eNOS/NO) and intake of nitrite have been considered major stimuli to increase NO.

Objective: We examined the effects of oral nitrite administration and aerobic exercise training on BP and arterial stiffness in Wistar rats.

Methods: Thirty-nine (39) young male Wistar rats were divided into the following groups (n = 9 or 10 per group): Sedentary-Control (SC), Sedentary-Nitrite (SN), Trained-Control (TC), and Trained-Nitrite (TN). They were submitted to aerobic physical training on treadmills for 8 weeks (50-60% of physical capacity, 1h/day, 5 days/week) or kept sedentary. In the last 6 days of training, oral nitrite was administered (15 mg/Kg by gavage). BP, arterial stiffness, and plasma and tissue nitrite concentrations were assessed after the training and oral nitrite administration period. The significant level was defined as p < 0.05.

Results: Oral administration of nitrite was effective in reducing arterial stiffness values (TN, -23%; and SN, -15%). Both groups that had only one type of intervention showed lower systolic BP compared with control (TC vs. SC, -14.23; and SN vs. SC, - 12.46).

Conclusion: We conclude that short-term oral administration for 6 days and an aerobic physical training program promote several hemodynamic benefits in male Wistar rats, such as improvements in arterial stiffness and BP. These responses suggest that physical training and sodium nitrite supplementation can be alternatives for the prevention and treatment of hypertension.

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