1例年轻免疫功能低下患者长期慢性感染SARS-CoV-2 P.2 VOI

IF 1.5 4区医学 Q4 INFECTIOUS DISEASES

Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI:10.1590/S1678-9946202466069

Camila Malta Romano, Vitor Gabriel Lopes da Silva, Luciane Sussuchi da Silva, Carolina Sanchez Aranda, Cristina Mendes de Oliveira, Marilda Mendonça Teixeira Siqueira, Elisa Cavalcante Pereira, Paola Cristina Resende, Nancy Cristina Junqueira Bellei, José Eduardo Levi, Maria Isabel de Moraes-Pinto

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引用次数: 0

摘要

2021年2月，一名免疫功能低下的患者感染了名为Zeta （P.2）的感兴趣的SARS-CoV-2变体。一年多后，他出现了症状性COVID-19，测序发现了相同的变体，累积了23个替换。该病例说明了一种特定SARS-CoV-2变体的宿主内进化，突出了对免疫功能低下患者进行基因组监测的重要性。

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Long-term chronic infection of a young immunocompromised patient by the SARS-CoV-2 P.2 VOI.

An immunocompromised patient was infected by the SARS-CoV-2 variant of interest named Zeta (P.2) in February 2021. More than one year later, he suffered from symptomatic COVID-19 and sequencing revealed the same variant, which accumulated 23 substitutions. This case illustrates intra-host evolution of a particular SARS-CoV-2 variant, highlighting the importance of genomic surveillance of immunocompromised patients.

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来源期刊

Revista Do Instituto De Medicina Tropical De Sao Paulo TROPICAL MEDICINE-

CiteScore

3.60

自引率

5.30%

发文量

100

审稿时长

6-12 weeks

期刊介绍： The Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is a journal devoted to research on different aspects of tropical infectious diseases. The journal welcomes original work on all infectious diseases, provided that data and results are directly linked to human health. The journal publishes, besides original articles, review articles, case reports, brief communications, and letters to the editor. The journal publishes manuscripts only in English. From 2016 on, the Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is published online only, maintaining the free access. For more information visit: - http://www.scielo.br/rimtsp - http://www.imt.usp.br/revista-imt/