心肺运动试验获得的生理储备和虚弱与血液透析患者全因死亡率的关系。

IF 8.5 1区医学 Q1 UROLOGY & NEPHROLOGY

Clinical Journal of the American Society of Nephrology Pub Date : 2024-12-18 DOI:10.2215/CJN.0000000621

Naoto Usui, Junichiro Nakata, Akimi Uehata, Sho Kojima, Shuji Ando, Masakazu Saitoh, Akihito Inatsu, Hideki Hisadome, Yuki Nishiyama, Yusuke Suzuki

引用次数: 0

摘要

背景：即使在没有虚弱的血液透析患者中，运动能力的潜在损害也是普遍存在的。心肺运动试验（CPET）可以检测生理储备，如心肺、肌肉和自主神经功能。我们假设这些指标可以准确判断血液透析患者的预后，并根据其与虚弱的关系进行分析。方法：在这项来自日本的血液透析患者的双中心前瞻性队列研究中，参与者接受了CPET和体能评估，以评估峰值摄氧量（VO2峰值，运动能力指标）、峰值工作速率（WR，肌肉功能指标）、呼吸当量二氧化碳（VE/VCO2）斜率（心脏储备指标）、心率储备（变时功能不全指标）和虚弱表型。生存率随访长达5年。结果：189例患者（中位[IQR]年龄：71[62,77]岁）的数据被分析。调整后，所有CPET指标均与全因死亡率呈一致的非线性关系：对于峰值VO2，风险比[HR] 0.79 [95% CI: 0.71, 0.88]， P结论：结果显示血液透析人群中脆弱表型的脆弱方面，CPET显示死亡风险的优势能力补充了这方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Association of Physiological Reserve Obtained from Cardiopulmonary Exercise Testing and Frailty with All-Cause Mortality in Patients on Hemodialysis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical Journal of the American Society of Nephrology 医学-泌尿学与肾脏学

CiteScore

12.20

自引率

3.10%

发文量

514

审稿时长

3-6 weeks

期刊介绍： The Clinical Journal of the American Society of Nephrology strives to establish itself as the foremost authority in communicating and influencing advances in clinical nephrology by (1) swiftly and effectively disseminating pivotal developments in clinical and translational research in nephrology, encompassing innovations in research methods and care delivery; (2) providing context for these advances in relation to future research directions and patient care; and (3) becoming a key voice on issues with potential implications for the clinical practice of nephrology, particularly within the United States. Original manuscript topics cover a range of areas, including Acid/Base and Electrolyte Disorders, Acute Kidney Injury and ICU Nephrology, Chronic Kidney Disease, Clinical Nephrology, Cystic Kidney Disease, Diabetes and the Kidney, Genetics, Geriatric and Palliative Nephrology, Glomerular and Tubulointerstitial Diseases, Hypertension, Maintenance Dialysis, Mineral Metabolism, Nephrolithiasis, and Transplantation.