黑巧克力对代谢功能障碍相关脂肪性肝炎患者低度内毒素血症的影响。

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2024-11-16 DOI:10.1016/j.nut.2024.112643

Arianna Pannunzio M.D. , Francesco Baratta M.D. , Enrico Maggio M.D. , Ilaria Maria Palumbo M.D. , Arianna Magna M.D. , Chiara Trivigno M.D. , Roberto Carnevale Ph.D. , Bartimoccia Simona Ph.D. , Vittoria Cammisotto Ph.D. , Gianpaolo Vidili M.D. , Pasquale Pignatelli M.D. , Maria Del Ben M.D. , Francesco Violi M.D. , Lorenzo Loffredo M.D.

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引用次数: 0

摘要

背景与目的：可可可能具有益生元效应，改善肠道屏障功能。然而，黑巧克力是否能降低代谢功能障碍相关脂肪性肝炎（MASH）患者的脂多糖（LPS）水平仍不清楚。本研究旨在评估黑巧克力与牛奶巧克力对MASH患者内毒素血症的影响。方法和结果：19名MASH患者被随机分配到一个交叉设计中，食用40克/天的黑巧克力（可可含量为85%）或40克/天的牛奶巧克力(结论：本研究表明，黑巧克力降低了MASH患者体内的LPS和zonulin循环水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Dark chocolate's impact on low-grade endotoxemia in metabolic dysfunction-associated steatohepatitis

Background and Aims

Cocoa may have prebiotic effects and improve gut barrier function. However, it remains unclear whether dark chocolate can reduce lipopolysaccharide (LPS) levels in patients with metabolic dysfunction–associated steatohepatitis (MASH). This study aims to evaluate the effect of dark chocolate compared to milk chocolate on endotoxemia in patients with MASH.

Methods and Results

Nineteen patients with MASH were randomly assigned in a crossover design to consume either 40 g/d of dark chocolate (>85% cocoa) or 40 g/d of milk chocolate (<35% cocoa) for 2 weeks to evaluate circulating levels of LPS and zonulin. A significant difference between treatments was observed in LPS (P = 0.04) and zonulin (P = 0.02) levels based on the ANOVA conducted on the crossover study data. Pairwise comparisons revealed that, compared to baseline, after 14 days of dark chocolate consumption, LPS levels decreased from 22 ± 4 to 19 ± 4 pg/dL (–15%), and zonulin levels decreased from 3.2 ± 0.9 to 2.5 ± 0.8 pg/mL (–20%). Linear correlation analysis indicated that the change (Δ) in LPS values before and after chocolate intake correlated with the change (Δ) in zonulin levels (R = 0.340, P = 0.03).

Conclusions

This study demonstrates that dark chocolate reduces circulating levels of LPS and zonulin in patients with MASH.

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.