在痴呆和衰老的纵向流行病学研究中进行性核上性麻痹的诊断前阶段：一个病例报告。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2024-12-19 DOI:10.2169/internalmedicine.4529-24

Kenta Ishii, Hisashi Takahashi, Misaki Kubota-Hanya, Rei Yasuda, Fumitoshi Niwa, Masaki Kondo, Toshiki Mizuno

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引用次数: 0

摘要

一名63岁的健康男性参加了一项关于痴呆和衰老的纵向流行病学研究。虽然他最初没有主观症状，运动功能正常，但语言流畅性测试分数逐渐下降，头部磁共振成像观察到额叶进行性萎缩。71岁，在核上凝视性麻痹后被诊断为进行性核上性麻痹（PSP），并出现步态障碍。这项纵向流行病学研究表明，言语症状和轻度额叶萎缩可能在PSP的运动前期很明显。

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Prediagnostic Phase of Progressive Supranuclear Palsy in a Longitudinal Epidemiological Study of Dementia and Aging: A Case Report.

A 63-year-old previously healthy man participated in a longitudinal epidemiologic study of dementia and aging. Although he initially showed no subjective symptoms and a normal motor function, verbal fluency test scores gradually declined, and progressive atrophy of the frontal lobes was observed on magnetic resonance imaging of the head. At 71 years old, progressive supranuclear palsy (PSP) was diagnosed after supranuclear gaze palsy, and gait disturbance developed. This longitudinal epidemiological study suggests that verbal symptoms and mild frontal lobe atrophy may be evident in the premotor phase of PSP.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.