J L Low, A Marcotte-Chénard, R Tremblay, H Islam, K Falkenhain, W M Mampuya, A Mari, A M McManus, E Riesco, J P Little
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The trial involved an initial resting control condition followed by two HIIT conditions [4 × 4-min HIIT (HIIT4) and 10 × 1-min HIIT (HIIT10)] completed in a randomized order 2-4 days apart. β cell function (glucose sensitivity) and insulin sensitivity were determined from a 2-h mixed-meal tolerance test performed 2 h after rest or HIIT. Both HIIT4 and HIIT10 significantly improved β cell glucose sensitivity compared with control (15 pmol/min/m<sup>2</sup>/[mmol/L], [95% confidence interval (CI) 6, 23]; <i>P</i> = 0.002 and 16 pmol/min/m<sup>2</sup>/[mmol/L], [95% CI 7, 25]; <i>P</i> = 0.002, respectively), with no difference between HIIT protocols (1 [-8, 10], <i>P</i> = 0.79). There were no significant differences in IS metrics (Matsuda index, OGIS, Stumvoli, and QUICKI) between the conditions. An acute bout of 4 × 4-min or 10 × 1-min HIIT improves β cell glucose sensitivity in postmenopausal females living with type 2 diabetes. ClinicalTrials.gov: NCT04986345.<b>NEW & NOTEWORTHY</b> This is the first study to explore the effects of acute high-intensity interval training (HIIT) on β cell function in postmenopausal women with type 2 diabetes. Our crossover trial compares two HIIT protocols, matched for total estimated energy expenditure, examining their impacts on β cell function and insulin sensitivity. Despite the absence of an insulin-sensitizing effect, we show robust effects of HIIT on β-cell function, including an improvement in β-cell glucose sensitivity.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"311-317"},"PeriodicalIF":3.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An acute bout of 4 × 4-min or 10 × 1-min HIIT improves β cell glucose sensitivity in postmenopausal females with type 2 diabetes: a secondary analysis.\",\"authors\":\"J L Low, A Marcotte-Chénard, R Tremblay, H Islam, K Falkenhain, W M Mampuya, A Mari, A M McManus, E Riesco, J P Little\",\"doi\":\"10.1152/japplphysiol.00777.2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Improvements in glycemic control following acute exercise are typically attributed to improved postexercise insulin sensitivity (IS) with comparatively little known about how acute exercise impacts β cell function, especially in postmenopausal females. We determined how two high-intensity interval training (HIIT) protocols, matched for total estimated energy expenditure, impact β cell function in postmenopausal females with type 2 diabetes. Thirteen postmenopausal females (70 ± 5 yr; 12 ± 7 yr since diagnosis, 80.9 ± 13.8 kg, 32.4 ± 5.6 kg·m<sup>2</sup>; HbA1c-49.8 ± 10.3 mmol/mol [6.7 ± 1.0]) living with type 2 diabetes were included in this semirandomized crossover trial. The trial involved an initial resting control condition followed by two HIIT conditions [4 × 4-min HIIT (HIIT4) and 10 × 1-min HIIT (HIIT10)] completed in a randomized order 2-4 days apart. β cell function (glucose sensitivity) and insulin sensitivity were determined from a 2-h mixed-meal tolerance test performed 2 h after rest or HIIT. Both HIIT4 and HIIT10 significantly improved β cell glucose sensitivity compared with control (15 pmol/min/m<sup>2</sup>/[mmol/L], [95% confidence interval (CI) 6, 23]; <i>P</i> = 0.002 and 16 pmol/min/m<sup>2</sup>/[mmol/L], [95% CI 7, 25]; <i>P</i> = 0.002, respectively), with no difference between HIIT protocols (1 [-8, 10], <i>P</i> = 0.79). There were no significant differences in IS metrics (Matsuda index, OGIS, Stumvoli, and QUICKI) between the conditions. An acute bout of 4 × 4-min or 10 × 1-min HIIT improves β cell glucose sensitivity in postmenopausal females living with type 2 diabetes. ClinicalTrials.gov: NCT04986345.<b>NEW & NOTEWORTHY</b> This is the first study to explore the effects of acute high-intensity interval training (HIIT) on β cell function in postmenopausal women with type 2 diabetes. Our crossover trial compares two HIIT protocols, matched for total estimated energy expenditure, examining their impacts on β cell function and insulin sensitivity. 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引用次数: 0
摘要
目的/假设：急性运动后血糖控制的改善通常归因于运动后胰岛素敏感性（IS）的改善，而对于急性运动对β细胞功能的影响，特别是绝经后女性的影响知之甚少。我们确定了两种高强度间歇训练（HIIT）方案，匹配总估计能量消耗，如何影响绝经后2型糖尿病女性患者的β细胞功能。方法：绝经后女性13例(70±5岁；确诊12±7年，80.9±13.8 kg, 32.4±5.6 kg*m2；HbA1c - 49.8±10.3 mmol/mol[6.7±1.0])的2型糖尿病患者纳入了这项半随机交叉试验。该试验包括初始静息对照条件，随后以随机顺序间隔2-4天完成两种HIIT条件[4 X 4分钟HIIT （HIIT4）和10 X 1分钟HIIT (HIIT10)]。细胞功能（葡萄糖敏感性）和胰岛素敏感性通过休息或HIIT后2小时进行的2小时混合膳食耐量试验来确定。结果：与对照组相比，HIIT4和hiit10均显著改善β细胞葡萄糖敏感性(15 pmol*min-1*m-2[mmol/L]-1, [95% CI 6, 23]；p= 0.002和16 pmol*min-1*m-2[mmol/L]-1， [95% CI 7, 25]；p= 0.002)， HIIT方案之间无差异（1 [- 8,10],p= 0.79）。两组间IS指标（Matsuda指数、OGIS、Stumvoli和QUICKI）无显著差异。结论/解释：急性期4 × 4分钟或10 × 1分钟HIIT可改善绝经后2型糖尿病女性患者的β细胞葡萄糖敏感性。
An acute bout of 4 × 4-min or 10 × 1-min HIIT improves β cell glucose sensitivity in postmenopausal females with type 2 diabetes: a secondary analysis.
Improvements in glycemic control following acute exercise are typically attributed to improved postexercise insulin sensitivity (IS) with comparatively little known about how acute exercise impacts β cell function, especially in postmenopausal females. We determined how two high-intensity interval training (HIIT) protocols, matched for total estimated energy expenditure, impact β cell function in postmenopausal females with type 2 diabetes. Thirteen postmenopausal females (70 ± 5 yr; 12 ± 7 yr since diagnosis, 80.9 ± 13.8 kg, 32.4 ± 5.6 kg·m2; HbA1c-49.8 ± 10.3 mmol/mol [6.7 ± 1.0]) living with type 2 diabetes were included in this semirandomized crossover trial. The trial involved an initial resting control condition followed by two HIIT conditions [4 × 4-min HIIT (HIIT4) and 10 × 1-min HIIT (HIIT10)] completed in a randomized order 2-4 days apart. β cell function (glucose sensitivity) and insulin sensitivity were determined from a 2-h mixed-meal tolerance test performed 2 h after rest or HIIT. Both HIIT4 and HIIT10 significantly improved β cell glucose sensitivity compared with control (15 pmol/min/m2/[mmol/L], [95% confidence interval (CI) 6, 23]; P = 0.002 and 16 pmol/min/m2/[mmol/L], [95% CI 7, 25]; P = 0.002, respectively), with no difference between HIIT protocols (1 [-8, 10], P = 0.79). There were no significant differences in IS metrics (Matsuda index, OGIS, Stumvoli, and QUICKI) between the conditions. An acute bout of 4 × 4-min or 10 × 1-min HIIT improves β cell glucose sensitivity in postmenopausal females living with type 2 diabetes. ClinicalTrials.gov: NCT04986345.NEW & NOTEWORTHY This is the first study to explore the effects of acute high-intensity interval training (HIIT) on β cell function in postmenopausal women with type 2 diabetes. Our crossover trial compares two HIIT protocols, matched for total estimated energy expenditure, examining their impacts on β cell function and insulin sensitivity. Despite the absence of an insulin-sensitizing effect, we show robust effects of HIIT on β-cell function, including an improvement in β-cell glucose sensitivity.
期刊介绍：
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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