溶酶体钙通道在减轻线粒体损伤和氧化应激中的作用。

IF 4.3 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2025-01-01 DOI:10.1016/j.ceca.2024.102986

Leandro C. Clementino , Andrew P. Thomas , Emily M. Rocha , Sabine Hilfiker

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引用次数: 0

摘要

游离脂肪酸升高和氧化应激可能是与各种心血管并发症相关的内皮功能障碍的致病因素。在最近的研究中，Feng和他的同事报告说，激活溶酶体Ca2+通道可能是一种可行的选择，可以通过促进溶酶体的生物发生和线粒体自噬来减轻氧化损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress

查看原文本刊更多论文

A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress

Elevated free fatty acids and oxidative stress may function as pathogenic factors in endothelial dysfunction that is associated with various cardiovascular complications. In recent work, Feng and colleagues report that activation of a lysosomal Ca²⁺ channel may be a viable option to alleviate oxidative damage by boosting lysosome biogenesis and mitophagy.

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes