一种新型静脉外膜氧合引流套管的研制与评价。

IF 3.1 3区 医学 Q2 ENGINEERING, BIOMEDICAL
ASAIO Journal Pub Date : 2025-03-01 Epub Date: 2024-12-19 DOI:10.1097/MAT.0000000000002360
Avishka Wickramarachchi, Saeedreza Zeibi Shirejini, Ashkan Vatani, Akshita Rana, Mehrdad Khamooshi, Michael Šeman, Sam Liao, Edwina Jap, Tuan H Nguyen, Karen Alt, Aidan Burrell, Vincent A Pellegrino, David M Kaye, Christoph E Hagemeyer, Shaun D Gregory
{"title":"一种新型静脉外膜氧合引流套管的研制与评价。","authors":"Avishka Wickramarachchi, Saeedreza Zeibi Shirejini, Ashkan Vatani, Akshita Rana, Mehrdad Khamooshi, Michael Šeman, Sam Liao, Edwina Jap, Tuan H Nguyen, Karen Alt, Aidan Burrell, Vincent A Pellegrino, David M Kaye, Christoph E Hagemeyer, Shaun D Gregory","doi":"10.1097/MAT.0000000000002360","DOIUrl":null,"url":null,"abstract":"<p><p>A critical factor in thrombus formation during venoarterial extracorporeal membrane oxygenation (VA ECMO) is prothrombotic flow dynamics generated by the drainage cannula's design. This study aimed to create and evaluate a novel drainage cannula design which optimized blood flow dynamics to reduce thrombus formation. Computational fluid dynamics (CFD) was used to iteratively vary drainage cannula design parameters such as inner wall shape and side hole shape. The final novel design was then placed in an ex vivo blood circulation loop, and compared against a Bio-Medicus cannula (n = 6, each). Clot volume, hemolysis, and other parameters were measured to assess thrombus formation markers. The novel design consisted of a parabolic inner wall profile with closely spaced side holes angled at 30º to align with flow. When tested in the ex vivo loop, the novel design resulted in lower instances (two vs . four) and volumes of clot in the cannula (360.5 ± 254.8 vs . 1258.0 ± 651.7 µl) when compared to the Bio-Medicus cannula. Results from tests assessing hemolysis, platelet activation, and other thrombotic markers revealed a noninferior relationship between the novel and Bio-Medicus designs. Future work will explore the clinical applicability of these findings.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"235-244"},"PeriodicalIF":3.1000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development and Evaluation of a Novel Drainage Cannula for Venoarterial Extracorporeal Membrane Oxygenation.\",\"authors\":\"Avishka Wickramarachchi, Saeedreza Zeibi Shirejini, Ashkan Vatani, Akshita Rana, Mehrdad Khamooshi, Michael Šeman, Sam Liao, Edwina Jap, Tuan H Nguyen, Karen Alt, Aidan Burrell, Vincent A Pellegrino, David M Kaye, Christoph E Hagemeyer, Shaun D Gregory\",\"doi\":\"10.1097/MAT.0000000000002360\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A critical factor in thrombus formation during venoarterial extracorporeal membrane oxygenation (VA ECMO) is prothrombotic flow dynamics generated by the drainage cannula's design. This study aimed to create and evaluate a novel drainage cannula design which optimized blood flow dynamics to reduce thrombus formation. Computational fluid dynamics (CFD) was used to iteratively vary drainage cannula design parameters such as inner wall shape and side hole shape. The final novel design was then placed in an ex vivo blood circulation loop, and compared against a Bio-Medicus cannula (n = 6, each). Clot volume, hemolysis, and other parameters were measured to assess thrombus formation markers. The novel design consisted of a parabolic inner wall profile with closely spaced side holes angled at 30º to align with flow. When tested in the ex vivo loop, the novel design resulted in lower instances (two vs . four) and volumes of clot in the cannula (360.5 ± 254.8 vs . 1258.0 ± 651.7 µl) when compared to the Bio-Medicus cannula. Results from tests assessing hemolysis, platelet activation, and other thrombotic markers revealed a noninferior relationship between the novel and Bio-Medicus designs. Future work will explore the clinical applicability of these findings.</p>\",\"PeriodicalId\":8844,\"journal\":{\"name\":\"ASAIO Journal\",\"volume\":\" \",\"pages\":\"235-244\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ASAIO Journal\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1097/MAT.0000000000002360\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ASAIO Journal","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1097/MAT.0000000000002360","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

摘要

在静脉动脉体外膜氧合(VA ECMO)过程中血栓形成的一个关键因素是由引流管设计产生的血栓前血流动力学。本研究旨在创造和评估一种新型引流管设计,优化血流动力学以减少血栓形成。利用计算流体力学(CFD)方法迭代改变引流管内壁形状和侧孔形状等设计参数。然后将最后的新设计放入离体血液循环循环中,并与Bio-Medicus插管(每种n = 6)进行比较。测量凝块体积、溶血和其他参数来评估血栓形成标志物。这种新颖的设计包括一个抛物线状的内壁轮廓,侧面孔以30º的角度紧密排列,以配合流动。在体外循环中进行测试时,与Bio-Medicus插管相比,新设计的插管中出现了更少的病例(2例vs. 4例)和血栓体积(360.5±254.8 μ l vs. 1258.0±651.7µl)。溶血、血小板活化和其他血栓标志物的测试结果显示,新型和Bio-Medicus设计之间存在非劣势关系。未来的工作将探讨这些发现的临床适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and Evaluation of a Novel Drainage Cannula for Venoarterial Extracorporeal Membrane Oxygenation.

A critical factor in thrombus formation during venoarterial extracorporeal membrane oxygenation (VA ECMO) is prothrombotic flow dynamics generated by the drainage cannula's design. This study aimed to create and evaluate a novel drainage cannula design which optimized blood flow dynamics to reduce thrombus formation. Computational fluid dynamics (CFD) was used to iteratively vary drainage cannula design parameters such as inner wall shape and side hole shape. The final novel design was then placed in an ex vivo blood circulation loop, and compared against a Bio-Medicus cannula (n = 6, each). Clot volume, hemolysis, and other parameters were measured to assess thrombus formation markers. The novel design consisted of a parabolic inner wall profile with closely spaced side holes angled at 30º to align with flow. When tested in the ex vivo loop, the novel design resulted in lower instances (two vs . four) and volumes of clot in the cannula (360.5 ± 254.8 vs . 1258.0 ± 651.7 µl) when compared to the Bio-Medicus cannula. Results from tests assessing hemolysis, platelet activation, and other thrombotic markers revealed a noninferior relationship between the novel and Bio-Medicus designs. Future work will explore the clinical applicability of these findings.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
ASAIO Journal
ASAIO Journal 医学-工程:生物医学
CiteScore
6.60
自引率
7.10%
发文量
651
审稿时长
4-8 weeks
期刊介绍: ASAIO Journal is in the forefront of artificial organ research and development. On the cutting edge of innovative technology, it features peer-reviewed articles of the highest quality that describe research, development, the most recent advances in the design of artificial organ devices and findings from initial testing. Bimonthly, the ASAIO Journal features state-of-the-art investigations, laboratory and clinical trials, and discussions and opinions from experts around the world. The official publication of the American Society for Artificial Internal Organs.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信