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IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-12-19 DOI:10.1016/j.chembiol.2024.11.008

Spenser H. Stone, Jeffrey C. Rathmell, Jackie E. Bader

引用次数: 0

摘要

肥胖是许多癌症的主要风险因素和不良预后指标。在最近一期的《科学免疫学》（Science Immunology）杂志上，Bagchi 等人发现，与肿瘤相关的巨噬细胞会上调 GPR65，以应对肥胖导致的肿瘤内酸性，从而降低效应器功能，促进肿瘤生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Macrophages make “sense” of obesity-driven acidity in the TME

Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intratumor acidity resulting in reduced effector function to promote tumor growth.¹

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.