母体补充鱼油可通过 GPR120 信号通路增强胎盘营养运输和乳腺分泌

IF 11.4 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Qihui Li, Qianzi Zhang, Senlin Su, Siwang Yang, Jiayuan Shao, Wutai Guan, Shihai Zhang
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引用次数: 0

摘要

导言:研究表明,孕妇在怀孕期间补充鱼油(FO)可改善妊娠结局。鱼油被认为是 n-3 多不饱和脂肪酸(n-3 PUFAs)的膳食来源。早期的研究主要集中在 n-3 多不饱和脂肪酸 n-3 PUFAs 对胎儿神经发育、视网膜成熟和新生儿行为的益处,但它们在妊娠晚期胎盘和哺乳期乳腺中的作用仍不清楚。方法 我们评估了 FO 对母体胎盘营养运输、乳腺乳汁合成和后代生长的影响。然后,我们通过体外实验探索了二十二碳六烯酸(DHA)影响胎盘滋养层细胞功能和乳腺上皮细胞营养物质分泌的分子机制。最后,还进行了脂多糖挑战实验,以了解母体补充 FO 在减轻后代肠道炎症方面的潜力。结果孕晚期母体补充 FO 可增加后代出生体重,这与母体胎盘血管化和营养物质转运体丰度增强有关。此外,母体在哺乳期补充 FO 可改善乳腺分泌,增加初乳和成熟乳汁中的脂肪、蛋白质和非脂固体含量,从而促进后代的生长。DHA 对胎盘滋养层细胞功能和乳腺上皮细胞营养物质分泌的刺激作用是由 GPR120 信号通路介导的。此外,母体补充 FO 可增强胎盘屏障,减少胎盘炎症和氧化应激,减轻脂多糖诱导的后代肠道炎症。此外,母体补充 FO 还能降低后代对肠道炎症的易感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Maternal fish oil supplementation enhances placental nutrient transport and mammary gland secretion via the GPR120 signaling pathway

Maternal fish oil supplementation enhances placental nutrient transport and mammary gland secretion via the GPR120 signaling pathway

Introduction

Maternal fish oil (FO) supplementation during pregnancy has been shown to improve pregnancy outcomes. FO is recognized as dietary source for n-3 polyunsaturated fatty acids (n-3 PUFAs). While early research has focused on the benefits of n-3 polyunsaturated fatty acids n-3 PUFAs for fetal neurodevelopment, retinal maturation and neonatal behavior, their roles in the placenta during late pregnancy and in the mammary gland during lactation still remain unknow.

Objectives

Here, we aim to clarify the mechanisms by which maternal supplementation with FO during pregnancy and lactation affects placental and mammary gland function.

Methods

We evaluated the effects of FO on maternal placental nutrient transport, mammary gland milk synthesis and offspring growth. We then explored the molecular mechanisms by which docosahexaenoic acid (DHA) affects the function of placental trophoblast cells and nutrient secretion of mammary epithelial cells through in vitro experiments. Finally, a lipopolysaccharide-challenged experiment was performed to access the potential of maternal FO supplementation in alleviating offspring intestinal inflammation.

Results

Maternal supplementation with FO during late pregnancy increased offspring birth weight, associated with enhanced maternal placental vascularization and nutrient transporter abundance. Additionally, maternal FO supplementation during lactation improved mammary gland secretion, increasing the fat, protein, and non-fat solids content in both colostrum and mature milk, thereby promoting offspring growth. The stimulatory effects of DHA on placental trophoblast cell function and nutrient secretion in mammary gland epithelial cells were mediated by GPR120 signaling pathways. Furthermore, maternal FO supplementation strengthened the placental barrier, reduced placental inflammation, oxidative stress and alleviated lipopolysaccharide-induced intestinal inflammation in offspring.

Conclusion

Maternal FO supplementation during late pregnancy and lactation enhances offspring growth by increasing placental nutrient transport and mammary gland secretion function, mediated by GPR120. Additionally, maternal FO supplementation reduces the susceptibility of offspring to intestinal inflammation.
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来源期刊
Journal of Advanced Research
Journal of Advanced Research Multidisciplinary-Multidisciplinary
CiteScore
21.60
自引率
0.90%
发文量
280
审稿时长
12 weeks
期刊介绍: Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.
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