阿尔茨海默病相关的 CD83（+）小胶质细胞与肠道、迷走神经和大脑中免疫球蛋白 G4 和人类巨细胞病毒的增加有关

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-12-19 DOI:10.1002/alz.14401

Benjamin P. Readhead, Diego F. Mastroeni, Qi Wang, Maria A. Sierra, Camila de Ávila, Tajudeen O. Jimoh, Jean-Vianney Haure-Mirande, Kristina E. Atanasoff, Jennifer Nolz, Crystal Suazo, Nathaniel J. Barton, Adrian R. Orszulak, Samantha M. Chigas, Khanh Tran, Anne Mirza, Krista Ryon, Jacqueline Proszynski, Deena Najjar, Joel T. Dudley, Sean T. H. Liu, Sam Gandy, Michelle E. Ehrlich, Eric Alsop, Jerry Antone, Rebecca Reiman, Cory Funk, Rebecca L. Best, Michael Jhatro, Kathy Kamath, John Shon, Timothy F. Kowalik, David A. Bennett, Winnie S. Liang, Geidy E. Serrano, Thomas G. Beach, Kendall Van Keuren-Jensen, Christopher E. Mason, Yingleong Chan, Elaine T. Lim, Domenico Tortorella, Eric M. Reiman

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Alzheimer's disease-associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain

While there may be microbial contributions to Alzheimer's disease (AD), findings have been inconclusive. We recently reported an AD-associated CD83(+) microglia subtype associated with increased immunoglobulin G4 (IgG4) in the transverse colon (TC).

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.