整合 C-H 活化/折叠环化：杂芳基系链噁唑基异喹啉酮的模块化途径

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-12-12 DOI:10.1039/d4cc06123c

Shubhajit Basak , Tripti Paul , Maniya V Nanjegowda , Tharmalingam Punniyamurthy

引用次数: 0

摘要

利用铑催化，实现了2-芳基恶唑啉与吡喃三唑的级联C-H活化/2倍环化，得到了杂芳基系结恶唑异喹啉酮。生物活性支架的协同环、功能基耐受性和后期骨骼编辑是其突出的实用特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Integrating C–H activation/2-fold annulation: a modular access to heteroaryl-tethered oxazoloisoquinolinones†

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Integrating C–H activation/2-fold annulation: a modular access to heteroaryl-tethered oxazoloisoquinolinones†

A cascade C–H activation/2-fold annulation of 2-aryloxazolines with pyridotriazoles has been achieved employing Rh-catalysis to afford heteroaryl-tethered oxazoloisoquinolinones. The synergistic annulations, functional group tolerance, and late-stage skeletal editing of the bioactive scaffolds are the salient practical features.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.