雌雄小鼠运动能力的纵向下降

Megan L Pajski, Rosario Maroto, Chris Byrd, Ted G Graber
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摘要

老年人口呈指数级增长。伴随衰老而来的是慢性疾病的发作、身体机能的衰退和生活质量的下降。因此,人口的增加将对卫生和长期保健系统的能力和财政可行性造成压力。开发与年龄相关的功能衰退的临床前模型对于推进延长健康寿命和延长独立性的治疗是必不可少的。在之前的横断面研究中,我们建立了一个强大的复合评分系统,我们称之为CFAB(综合功能评估系统)。CFAB测量身体功能和运动能力,使用经过验证的决定因素来测量整体运动功能、前肢力量、四肢力量/耐力、有氧能力和意志运动/活动率。在目前的工作中,我们使用CFAB跟踪雄性和雌性C57BL/6小鼠的整个生命周期(在6、12、18、24和28个月大时测量CFAB)。总体而言,我们发现随着小鼠年龄的增长,功能下降具有统计学意义,雄性和雌性在轨迹和斜率上存在一些差异。我们还确定了体重变化在性别之间的差异,并跟踪了女性的身体成分(脂肪百分比,使用磁共振成像)。在一组小鼠中,我们跟踪了体内收缩生理学,注意到足底屈肌最大等距扭矩的下降。总之,我们的数据表明男性和女性以不同的速度下降。我们证实了CFAB在追踪男性和女性运动能力和身体健康纵向变化方面的有效性,进一步验证了该系统追踪与年龄相关的功能衰退的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Longitudinal Decline of Exercise Capacity in Male and Female Mice
The population of older adults is exponentially expanding. Alongside aging comes the onset of chronic disease, decline of functional capacity, and reduced quality of life. Thus, this population increase will stress the capacity and financial viability of health and long-term care systems. Developing pre-clinical models for age-related functional decline is imperative to advancing therapies that extend healthspan and prolong independence. Previously in a cross-sectional study, we established a powerful composite scoring system we termed CFAB (comprehensive functional assessment battery). CFAB measures physical function and exercise capacity using well-validated determinants to measure overall motor function, fore-limb strength, four-limb strength/endurance, aerobic capacity, and volitional exercise/activity rate. In the current work, we used CFAB to track cohorts of male and female C57BL/6 mice over the lifespan (measuring CFAB at 6, 12, 18, 24, and 28 months of age). Overall, we found statistically significantly declining function as the mice aged, with some differences between males and females in trajectory and slope. We also determined that body mass changes presented differently between sexes, and tracked body composition (fat percentage, using magnetic resonance imagery) in females. In a subset of mice, we tracked in vivo contractile physiology noting declines in plantar flexor maximum isometric torque. In summary, our data suggest that males and females declined at different rates. We confirmed the efficacy of CFAB to track longitudinal changes in exercise capacity and physical fitness in both males and females, further validating the system to track age-related functional decline.
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