Trimodal brain imaging: A novel approach for simultaneous investigation of human brain function.

While advancements have improved the extent to which individual brain imaging approaches capture information regarding spatial or temporal dynamics of brain activity, the connections between these aspects and their relation to psychological functioning remain only partially understood. Acquisition and integration across multiple brain imaging modalities allows for the possible clarification of these connections. The present review provides an overview of three complementary modalities - functional magnetic resonance imaging (fMRI), electroencephalography/event-related potentials (EEG/ERP), and event-related optical signals (EROS) - and discusses progress and considerations for each modality, along with a summary of a novel protocol for acquiring them simultaneously. Initial evidence points to the feasibility of acquiring and integrating multiple measures of brain function that allows for addressing questions in ways not otherwise possible using traditional approaches. Simultaneous trimodal brain imaging in humans provides new possibilities for clarifying spatiotemporal dynamics of brain activity and for identifying multifaceted associations with measures of individual differences and important health outcomes.