巴西东北部黑腹果蝇辐射抗性的证据。

Maria Gislaine Pereira, Erima Maria de Amorim, Aleson Aparecido da Silva, Danubia Guimarães-Silva, Andre Morgado Esteves, Claudia Rohde
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引用次数: 0

摘要

背景:电离辐射可造成细胞损伤,其严重程度取决于剂量、照射时间和穿透细胞的能力。一些研究表明,遗传和表观遗传机制使生物体能够发展出适应性性状并增强其修复DNA损伤的能力。巴西东北部是一个富含铀和钍的岩石露头地区,是研究自然辐射及其对自然种群影响的理想场所。本研究提供了居住在Cerro cor市(CC-res)的黑腹果蝇(Drosophila melanogaster)自然品系后代辐射抗性的证据,该环境具有高水平的氡-222。材料和方法:采用彗星试验对在相同实验室条件下饲养7至13个月的对照组CC-res和Oregon-R (OR)的后代进行遗传毒性评估。在干湿季节,成虫及其子代幼虫分别暴露于Cerro cor环境6 d。只有CC-res的损伤指数和频率较低。为了证实这些菌株的辐射抗性,在培养16个月后,将这些菌株暴露在受控剂量的伽马辐射中。结果和结论:与OR菌株相比,CC-res表现出明显较低的损伤水平,并且仅在OR组中观察到明显的剂量反应效应。研究结果支持CC-res菌株存在辐射抗性,并强调需要对巴西自然环境辐射的影响进行进一步的体内研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evidences of radioresistance in Drosophila melanogaster from Northeastern Brazil.

Background: Ionizing radiation can inflict cellular damage, the severity of which is determined by the dose, exposure duration, and its capacity to penetrate cells. Some studies have demonstrated that genetic and epigenetic mechanisms have enabled organisms to develop adaptive traits and enhance their ability to repair DNA damage. Northeastern Brazil, a region containing rocky outcrops rich in uranium and thorium, is an ideal scenario to study natural radiation and its effects on natural populations. This study presents evidence of radioresistance in the offspring of a natural strain of Drosophila melanogaster resident in the municipality of Cerro Corá (CC-res), an environment with high levels of radon-222.

Material and methods: Genotoxicity was assessed using the comet assay in offspring of the CC-res and Oregon-R (OR), the control group, both reared under the same laboratory conditions for between 7 and 13 months. The adults and their offspring larvae were exposed to the Cerro Corá environment for 6 days during the dry and wet seasons. Low damage index and frequency were observed only in the CC-res. To confirm the radioresistance, the same strains were exposed after 16 months of cultivation to controlled doses of gamma radiation.

Results and conclusions: CC-res exhibited significantly lower levels of damage compared to the OR strain, with a clear dose-response effect to the irradiation observed exclusively in the OR group. The results support the occurrence of radioresistance in the CC-res strain and underscore the need for further in vivo studies investigations into the impact of Brazil's natural environmental radiation.

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