经颅交流电刺激对睡眠后脑电图频谱功率的影响：一项随机交叉研究。

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2025-02-01 DOI:10.1016/j.sleep.2024.12.011

Yuan Shi , Xin Tian , Taomei Li , Yuexia Hu , Yuqing Xie , Huixian Li , Yun Li , Ning Jiang , Xiangdong Tang , Yanyan Wang

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引用次数: 0

摘要

目的：探讨经颅交流电刺激（tACS）对睡眠脑振荡的即时影响。方法：36名健康受试者随机接受tACS和假刺激，采用交叉设计，中间间隔一周的洗脱期。刺激后进行2 h小睡多导睡眠图（PSG）获取脑电图（EEG）数据和客观睡眠变量，并在小睡结束时收集自我报告的主观睡眠参数。对脑电图数据进行脑电图频谱分析，得到小睡期间各睡眠阶段的绝对功率和相对功率。使用Spearman或Pearson相关系数分析权力值与客观和主观测量之间的关联。结果：在N2和N3睡眠阶段，与假手术组相比，tACS组在慢波活动（SWA）和δ频段的功率更高，α、sigma和β功率值更低。SWA和δ功率与睡眠持续时间和睡眠效率相关参数呈正相关；而alpha， sigma和beta功率与睡眠潜伏期延长和清醒相关变量呈正相关。PSG、自我报告和睡眠日记测量的客观和主观睡眠参数在tACS组和假手术组之间具有可比性。结论：我们的研究结果支持tACS在睡眠脑电图的微观结构上促进睡眠深度，表现为低频频谱功率增加，高频频谱功率降低。本研究注册号为ChiCTR2200063729。

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The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study

Objective

To evaluate the instant impact of transcranial alternating current stimulation (tACS) on sleep brain oscillations.

Methods

Thirty-six healthy subjects were randomly assigned to receive tACS and sham stimulation in a crossover design separated by a one-week washout period. After stimulation, a 2-h nap polysomnography (PSG) was performed to obtain Electroencephalogram (EEG) data and objective sleep variables, and self-reported subjective sleep parameters were collected at the end of the nap. EEG spectral analyses were conducted on the EEG data to obtain the absolute and relative power for each sleep stage during the nap. The associations between power values and objective and subjective measurements were analyzed using Spearman or Pearson correlation coefficients.

Results

The tACS group presented higher power in slow wave activity (SWA) and delta frequency bands and lower alpha, sigma and beta power values compared to the sham group during the N2 and N3 sleep stages. SWA and delta power were positively associated with sleep duration and sleep efficiency relevant parameters; while alpha, sigma and beta power were positively associated with prolonged sleep latency and wakefulness related variables. PSG, self-reported and sleep diary measured objective and subjective sleep parameters were comparable between the tACS and the sham groups.

Conclusion

Our results support that tACS could promote sleep depth in microstructure of sleep EEG, manifesting as an increase in EEG spectral power in low frequency bands and a decrease in high frequency bands.

The registration number of this study is ChiCTR2200063729.

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.