镰状细胞病年轻患者神经性疼痛的筛查及其影响

IF 2.4 3区 医学 Q2 HEMATOLOGY
Amira Adly, Maha Mohammed, Ahmed Aboata, Ghada Wassif, Marwa Nassef, Sara Makkeyah
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引用次数: 0

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
Screening and Impact of Neuropathic Pain in Young Individuals With Sickle Cell Disease.

Objective: To assess the frequency of neuropathic pain (NP) and its impact in young patients with sickle cell disease (SCD).

Methods: We used the ID-Pain (ID-P) questionnaire and a bedside clinical sensory testing (CST) as screening tools for NP and performed sensory nerve conduction study (SNCS) for all the participants. The impact of pain was assessed using Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires and Pediatric Quality of Life Inventory (PedsQL) SCD module.

Results: The mean age was 12.4 years. The ID-P questionnaire revealed that 20.5% of patients likely had NP, while 10 (34%) of the participants had abnormal CST, and only two patients (4.5%) had abnormal SNCS. On the PROMIS pain scores, the mean pain intensity score was 7.9 ± 2.0. Pain interference was the most affected domain in both patients and parent proxy reports (mean ± SD T-score 63.4 ± 6.6 and 65.2 ± 6.6, respectively) which was worse than other domains including pain quality-sensory and affective, and pain behavior (median T-scores of 47.8, 63.0, and 56.2, respectively). The mean global health-related quality of life (HRQoL) score of the children was 50.3 ± 12.1 indicating poor quality of life.

Conclusion: We report the utility of simple tools like ID-P questionnaire and CST for screening of NP in young individuals with SCD.

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来源期刊
Pediatric Blood & Cancer
Pediatric Blood & Cancer 医学-小儿科
CiteScore
4.90
自引率
9.40%
发文量
546
审稿时长
1.5 months
期刊介绍: Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.
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