假角藻素G，一种从假角藻属海绵中提取的含有氰基的新sammaplysin衍生物。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.267

Shin-Ichiro Kurimoto, Kouta Inoue, Taito Ohno, Takaaki Kubota

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引用次数: 0

摘要

从冲绳海绵Pseudoceratina sp.中获得了一种新的psammaplysin衍生物ceratinadin G(1)，并通过光谱和光谱分析对其总体结构进行了澄清。通过与已知的psammaplysin衍生物psammaplysin F(2)的NMR和ECD数据比较，确定了化合物1的绝对构型。Ceratinadin G(1)是一种罕见的含有氰基的腈，如氨基乙腈，是第一个含有氰基的psammaplysin衍生物。体外实验表明，化合物1对L1210小鼠白血病细胞和KB表皮样癌细胞具有中等的细胞毒性。

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Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina.

A new psammaplysin derivative, ceratinadin G (1), was obtained from the Okinawan marine sponge Pseudoceratina sp., and the gross structure was clarified through spectroscopic and spectrometric analyses. The absolute configuration of compound 1 was established by comparing its NMR and ECD data with those of the known psammaplysin derivative, psammaplysin F (2). Ceratinadin G (1) is a rare nitrile containing a cyano group as aminoacetonitrile, and is the first psammaplysin derivative possessing a cyano group. In vitro assays indicated that compound 1 displayed moderate cytotoxicity against L1210 murine leukemia cells and KB epidermoid carcinoma cells.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.