L. I. Arabova, L. V. Chumikina, R. I. Arabov, A. F. Topunov
{"title":"医用吲哚-3-乙酸（综述）","authors":"L. I. Arabova, L. V. Chumikina, R. I. Arabov, A. F. Topunov","doi":"10.1134/S0003683824604670","DOIUrl":null,"url":null,"abstract":"<p>Therapeutic effect of many plants is associated with the presence of various bioactive substances in them. The plant hormones—phytohormones—can be distinguished among these substances. When ingested into the human body, they affect physiological processes such as inflammation, glucose uptake, cell division, and resistance to diseases. It is hypothesized that phytohormones may be used as drugs with no side effects. One of them could be the phytohormone indolyl-3-acetic acid (IAA), which is a heteroauxin and can be synthesized by some microorganisms and animals, including mammals. This phytohormone is an important derivative of indole, which is catabolized from dietary tryptophan by the intestinal microbiota. IAA can scavenge free radicals, inhibit oxidative stress, and reduce the production of proinflammatory cytokines. As a ligand of the aryl hydrocarbon receptor, IAA can regulate intestinal homeostasis and suppress inflammatory responses. This review summarizes the current literature data on the vital role of IAA in the treatment of cancer, type 2 diabetes, rheumatoid arthritis, liver disease, Alzheimer’s disease, dental diseases, and microbial skin diseases. The purpose of this review is to draw attention and interest to IAA as a promising therapeutic drug.</p>","PeriodicalId":466,"journal":{"name":"Applied Biochemistry and Microbiology","volume":"60 6","pages":"993 - 1009"},"PeriodicalIF":1.0000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Indolyl-3-Acetic Acid for Medical Use (Review)\",\"authors\":\"L. I. Arabova, L. V. Chumikina, R. I. Arabov, A. F. Topunov\",\"doi\":\"10.1134/S0003683824604670\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Therapeutic effect of many plants is associated with the presence of various bioactive substances in them. The plant hormones—phytohormones—can be distinguished among these substances. When ingested into the human body, they affect physiological processes such as inflammation, glucose uptake, cell division, and resistance to diseases. It is hypothesized that phytohormones may be used as drugs with no side effects. One of them could be the phytohormone indolyl-3-acetic acid (IAA), which is a heteroauxin and can be synthesized by some microorganisms and animals, including mammals. This phytohormone is an important derivative of indole, which is catabolized from dietary tryptophan by the intestinal microbiota. IAA can scavenge free radicals, inhibit oxidative stress, and reduce the production of proinflammatory cytokines. As a ligand of the aryl hydrocarbon receptor, IAA can regulate intestinal homeostasis and suppress inflammatory responses. This review summarizes the current literature data on the vital role of IAA in the treatment of cancer, type 2 diabetes, rheumatoid arthritis, liver disease, Alzheimer’s disease, dental diseases, and microbial skin diseases. The purpose of this review is to draw attention and interest to IAA as a promising therapeutic drug.</p>\",\"PeriodicalId\":466,\"journal\":{\"name\":\"Applied Biochemistry and Microbiology\",\"volume\":\"60 6\",\"pages\":\"993 - 1009\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-12-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Biochemistry and Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S0003683824604670\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Biochemistry and Microbiology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S0003683824604670","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Therapeutic effect of many plants is associated with the presence of various bioactive substances in them. The plant hormones—phytohormones—can be distinguished among these substances. When ingested into the human body, they affect physiological processes such as inflammation, glucose uptake, cell division, and resistance to diseases. It is hypothesized that phytohormones may be used as drugs with no side effects. One of them could be the phytohormone indolyl-3-acetic acid (IAA), which is a heteroauxin and can be synthesized by some microorganisms and animals, including mammals. This phytohormone is an important derivative of indole, which is catabolized from dietary tryptophan by the intestinal microbiota. IAA can scavenge free radicals, inhibit oxidative stress, and reduce the production of proinflammatory cytokines. As a ligand of the aryl hydrocarbon receptor, IAA can regulate intestinal homeostasis and suppress inflammatory responses. This review summarizes the current literature data on the vital role of IAA in the treatment of cancer, type 2 diabetes, rheumatoid arthritis, liver disease, Alzheimer’s disease, dental diseases, and microbial skin diseases. The purpose of this review is to draw attention and interest to IAA as a promising therapeutic drug.
期刊介绍：
Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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