基于含氮杂环和 1,5-二取代 3,7-二氮杂双环[3.3.1]壬烷-9-酮的杂化化合物的合成及其生物学特性

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2024-12-17 DOI:10.1134/S107036322411001X

A. A. Harutyunyan, S. G. Israelyan, M. R. Hakobyan, M. S. Safaryan, R. A. Madoyan, A. G. Sukiasyan, K. A. Gevorkyan, A. D. Harutyunyan, A. S. Sargsyan, A. A. Hambardzumyan, H. A. Karapetyan, A. A. Mnatsakanyan, H. A. Panosyan, M. Yu. Danghyan, S. P. Gasparyan

{"title":"基于含氮杂环和 1,5-二取代 3,7-二氮杂双环[3.3.1]壬烷-9-酮的杂化化合物的合成及其生物学特性","authors":"A. A. Harutyunyan, S. G. Israelyan, M. R. Hakobyan, M. S. Safaryan, R. A. Madoyan, A. G. Sukiasyan, K. A. Gevorkyan, A. D. Harutyunyan, A. S. Sargsyan, A. A. Hambardzumyan, H. A. Karapetyan, A. A. Mnatsakanyan, H. A. Panosyan, M. Yu. Danghyan, S. P. Gasparyan","doi":"10.1134/S107036322411001X","DOIUrl":null,"url":null,"abstract":"The reaction of aromatic aldehydes and 3-(heteryl)methyl-4-methoxybenzaldehydes with 1,5-disubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones afforded 2-aryl(hetaryl)-5,7-dimethyl-1,3-diazaadamantane-6-ones. 3-(Heteryl)methyl-4-methoxybenzaldehydes were obtained by alkylation of nitrogen-containing heterocycles (N1-functionalized uracil and 5-halouracils, N3-functionalized 6-methylpyrimidin- and quinazolin-4(3H)-ones, benzotriazole, quinoline, benzoxazole) with 3-chloromethyl-4-methoxylbenzaldehyde. Antibacterial and fungicidal properties of the synthesized compounds were studied.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 11","pages":"2809 - 2823"},"PeriodicalIF":0.9000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Biological Properties of Hybrid Compounds Based on Nitrogen-Containing Heterocycles and 1,5-Disubstituted 3,7-Diazabicyclo[3.3.1]nonan-9-ones\",\"authors\":\"A. A. Harutyunyan, S. G. Israelyan, M. R. Hakobyan, M. S. Safaryan, R. A. Madoyan, A. G. Sukiasyan, K. A. Gevorkyan, A. D. Harutyunyan, A. S. Sargsyan, A. A. Hambardzumyan, H. A. Karapetyan, A. A. Mnatsakanyan, H. A. Panosyan, M. Yu. Danghyan, S. P. Gasparyan\",\"doi\":\"10.1134/S107036322411001X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The reaction of aromatic aldehydes and 3-(heteryl)methyl-4-methoxybenzaldehydes with 1,5-disubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones afforded 2-aryl(hetaryl)-5,7-dimethyl-1,3-diazaadamantane-6-ones. 3-(Heteryl)methyl-4-methoxybenzaldehydes were obtained by alkylation of nitrogen-containing heterocycles (N1-functionalized uracil and 5-halouracils, N3-functionalized 6-methylpyrimidin- and quinazolin-4(3H)-ones, benzotriazole, quinoline, benzoxazole) with 3-chloromethyl-4-methoxylbenzaldehyde. Antibacterial and fungicidal properties of the synthesized compounds were studied.\",\"PeriodicalId\":761,\"journal\":{\"name\":\"Russian Journal of General Chemistry\",\"volume\":\"94 11\",\"pages\":\"2809 - 2823\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of General Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S107036322411001X\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S107036322411001X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

芳香族醛与3-（杂基）甲基-4-甲氧基苯甲醛与1,5-二取代3,7-重氮杂环[3.3.1]nonan-9- 1反应得到2-芳基（己基）-5,7-二甲基-1,3-重氮杂adaman -6- 1。3-氯甲基-4-甲氧基苯甲醛与氮杂环（n-官能化的尿嘧啶和5-卤脲嘧啶，n-官能化的6-甲基嘧啶和喹唑啉-4(3H)-酮，苯并三唑，喹啉，苯并恶唑）烷基化得到3-（杂基）甲基-4-甲氧基苯甲醛。研究了合成的化合物的抑菌和杀真菌性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Biological Properties of Hybrid Compounds Based on Nitrogen-Containing Heterocycles and 1,5-Disubstituted 3,7-Diazabicyclo[3.3.1]nonan-9-ones

查看原文本刊更多论文

Synthesis and Biological Properties of Hybrid Compounds Based on Nitrogen-Containing Heterocycles and 1,5-Disubstituted 3,7-Diazabicyclo[3.3.1]nonan-9-ones

The reaction of aromatic aldehydes and 3-(heteryl)methyl-4-methoxybenzaldehydes with 1,5-disubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones afforded 2-aryl(hetaryl)-5,7-dimethyl-1,3-diazaadamantane-6-ones. 3-(Heteryl)methyl-4-methoxybenzaldehydes were obtained by alkylation of nitrogen-containing heterocycles (N¹-functionalized uracil and 5-halouracils, N³-functionalized 6-methylpyrimidin- and quinazolin-4(3H)-ones, benzotriazole, quinoline, benzoxazole) with 3-chloromethyl-4-methoxylbenzaldehyde. Antibacterial and fungicidal properties of the synthesized compounds were studied.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.