2-烷基杂环芳烃衍生物与溴甲基烯烃级联Michael/SN2/芳构化反应无金属合成功能化吲哚

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2024-12-08 DOI:10.1021/acsomega.4c0929510.1021/acsomega.4c09295

Kangbiao Chen, Rui Zhou, Gaofeng Zhu, Lei Tang, Lu Huang* and Qing He*,

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引用次数: 0

摘要

建立了一种2-吡啶乙酸酯与溴甲基烯烃无过渡金属多米诺Michael/SN2/芳构化环。含有各种取代基的广泛底物与本方法兼容，并提供具有中等至优异收率（高达99%收率）的功能化吲哚。此外，通过放大反应和进一步转化为其他有价值的化合物，该方法的潜在实用性脱颖而出。在我们看来，本研究是通过无金属策略快速构建吲哚嗪衍生物的重要补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metal-Free Synthesis of Functionalized Indolizines via a Cascade Michael/SN2/Aromatization Reaction of 2-Alkylazaarene Derivatives with Bromonitroolefins

A transition metal-free domino Michael/S_N2/aromatization annulation of 2-pyridylacetates with bromonitroolefins has been developed. A wide range of substrates containing various substituted groups was compatible with the present methodology and afforded functionalized indolizines with moderate to excellent yield (up to 99% yield). In addition, the potential practicality of the method stood out through scale-up reactions and further transformations to other valuable compounds. In our view, this study is an essential complement for the rapid construction of indolizine derivatives through a metal-free strategy.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.