滑膜先天免疫衰竭与膝关节骨关节炎患者疼痛加重有关

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-12-17 DOI:10.1002/art.43089

Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton

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引用次数: 0

摘要

膝关节骨性关节炎（OA）是最常见的致残性关节疾病，不受控制的疼痛仍然是治疗膝关节骨性关节炎（OA）的主要临床挑战。更严重的疼痛与滑膜先天免疫细胞浸润（滑膜炎）有关，但先天免疫调节细胞在疼痛中的作用尚不清楚。我们的目的是确定滑膜先天免疫细胞亚群和病理生理机制与膝关节OA患者更严重的疼痛相关。

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Synovial innate immune exhaustion is associated with worse pain in knee osteoarthritis

Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune regulatory cells in pain is unknown. Our objective was to identify synovial innate immune cell subsets and pathophysiologic mechanisms associated with worse pain in patients with knee OA.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.