Qian Yang, Tom Defoirdt
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摘要

法定人数感应抑制是一种很有前景的控制细菌感染的新方法。然而,目前还不清楚的是,法定人数感应抑制是否会对病原体种群中对法定人数感应抑制的抗药性传播造成选择性压力。以前的研究试图通过使用合成生长介质来回答这个问题,结果发现抗药性是否会扩散完全取决于研究环境。因此,抗药性的传播应该在最终重要的环境中进行研究:在宿主感染期间的体内。在这里,我们利用对法定量感应抑制剂敏感和抗性的拟态菌,表明如果病原体种群中的初始抗性频率较低,那么在长达 35 个感染和传播周期中,对法定量感应抑制剂的抗性不会在宿主相关的坎贝尔弧菌种群中扩散,而如果抗性已经很普遍,那么抗性会进一步增加到 100%。不过,即使在后一种情况下,抗药性的传播速度也比相同条件下抗生素抗药性的传播速度要慢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Weak selection for resistance to quorum sensing inhibition during multiple host infection cycles
Quorum sensing inhibition is a promising novel approach to control bacterial infections. However, it is not clear whether quorum sensing inhibition will impose selective pressure for the spread of resistance against quorum sensing inhibition in pathogen populations. Previous research tried to answer this question by using synthetic growth media, and this revealed that whether or not resistance will spread completely depends on the environment in which it is studied. Therefore, the spread of resistance should be studied in the environment where it ultimately matters: in vivo during infection of a host. Here, using quorum sensing inhibitor-susceptible and -resistant mimics, we show that resistance to quorum sensing inhibition does not spread in host-associated populations of Vibrio campbellii during up to 35 cycles of infection and transmission if the initial frequency of the resistance is low in the pathogen population, whereas it further increases to 100% if it is already prevalent. However, even in the latter case, the resistance spreads at a slower pace than resistance to antibiotics spreads under the same conditions.
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