{"title":"普鲁士尼茨粪便杆菌:在癌症研究中具有多重潜在影响的一个物种","authors":"Rodrigo Formiga, Harry Sokol","doi":"10.1136/gutjnl-2024-334338","DOIUrl":null,"url":null,"abstract":"The gut microbiota is pivotal for maintaining health through beneficial symbiotic interaction with the host supporting the homeostasis of the gastrointestinal tract but also of the majority of extraintestinal organs. Alterations in the gut microbiome have been linked to the pathogenesis of various diseases, including cancer, which remains a leading cause of mortality worldwide. The colonisation or overgrowth of certain bacterial species at the expense of others has been implicated in tumorigenesis. For instance, Helicobacter pylori infection is known to cause chronic inflammation and significantly increases the risk of developing gastric cancer, while Bacteroides fragilis and Fusobacterium nucleatum overgrowth have been associated with colorectal cancer (CRC). Consequently, several microbiota-based strategies have been developed to regulate cancer progression, enhance immune responses towards tumorous cells and improve the effectiveness of current anticancer therapies.1 Among the most abundant bacteria in the healthy human gut microbiota, Faecalibacterium prausnitzii , an anaerobic member of the Clostridium IV group, is significantly reduced in patients with different types of cancers.2 3 Several studies suggest that this species may have direct antitumour effects against breast cancer and CRC,3 4 or alternatively boost the response to chemotherapy, particularly the immune …","PeriodicalId":12825,"journal":{"name":"Gut","volume":"11 1","pages":""},"PeriodicalIF":23.0000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Faecalibacterium prausnitzii: one species with multiple potential implications in cancer research\",\"authors\":\"Rodrigo Formiga, Harry Sokol\",\"doi\":\"10.1136/gutjnl-2024-334338\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The gut microbiota is pivotal for maintaining health through beneficial symbiotic interaction with the host supporting the homeostasis of the gastrointestinal tract but also of the majority of extraintestinal organs. Alterations in the gut microbiome have been linked to the pathogenesis of various diseases, including cancer, which remains a leading cause of mortality worldwide. The colonisation or overgrowth of certain bacterial species at the expense of others has been implicated in tumorigenesis. For instance, Helicobacter pylori infection is known to cause chronic inflammation and significantly increases the risk of developing gastric cancer, while Bacteroides fragilis and Fusobacterium nucleatum overgrowth have been associated with colorectal cancer (CRC). Consequently, several microbiota-based strategies have been developed to regulate cancer progression, enhance immune responses towards tumorous cells and improve the effectiveness of current anticancer therapies.1 Among the most abundant bacteria in the healthy human gut microbiota, Faecalibacterium prausnitzii , an anaerobic member of the Clostridium IV group, is significantly reduced in patients with different types of cancers.2 3 Several studies suggest that this species may have direct antitumour effects against breast cancer and CRC,3 4 or alternatively boost the response to chemotherapy, particularly the immune …\",\"PeriodicalId\":12825,\"journal\":{\"name\":\"Gut\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":23.0000,\"publicationDate\":\"2024-12-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gut\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/gutjnl-2024-334338\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/gutjnl-2024-334338","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
肠道微生物群通过与宿主进行有益的共生互动来维持健康,不仅支持胃肠道的平衡,还支持大多数肠道外器官的平衡。肠道微生物群的变化与包括癌症在内的各种疾病的发病机制有关,而癌症仍然是全球死亡的主要原因。某些细菌物种的定植或过度生长,牺牲了其他细菌物种的生长,这与肿瘤的发生有关。例如,幽门螺杆菌感染会导致慢性炎症,并显著增加罹患胃癌的风险,而脆弱乳杆菌和核酸镰刀菌的过度生长则与结直肠癌(CRC)有关。因此,人们开发了一些基于微生物群的策略,以调控癌症进展,增强对肿瘤细胞的免疫反应,并提高目前抗癌疗法的效果。在健康人肠道微生物群中最丰富的细菌中,梭状芽孢杆菌(Faecalibacterium prausnitzii)是梭状芽孢杆菌 IV 组中的厌氧菌,在不同类型癌症患者中的数量明显减少。2 3 一些研究表明,该菌种可能对乳腺癌和 CRC 有直接的抗肿瘤作用,3 4 或者可以增强对化疗的反应,尤其是免疫反应。
Faecalibacterium prausnitzii: one species with multiple potential implications in cancer research
The gut microbiota is pivotal for maintaining health through beneficial symbiotic interaction with the host supporting the homeostasis of the gastrointestinal tract but also of the majority of extraintestinal organs. Alterations in the gut microbiome have been linked to the pathogenesis of various diseases, including cancer, which remains a leading cause of mortality worldwide. The colonisation or overgrowth of certain bacterial species at the expense of others has been implicated in tumorigenesis. For instance, Helicobacter pylori infection is known to cause chronic inflammation and significantly increases the risk of developing gastric cancer, while Bacteroides fragilis and Fusobacterium nucleatum overgrowth have been associated with colorectal cancer (CRC). Consequently, several microbiota-based strategies have been developed to regulate cancer progression, enhance immune responses towards tumorous cells and improve the effectiveness of current anticancer therapies.1 Among the most abundant bacteria in the healthy human gut microbiota, Faecalibacterium prausnitzii , an anaerobic member of the Clostridium IV group, is significantly reduced in patients with different types of cancers.2 3 Several studies suggest that this species may have direct antitumour effects against breast cancer and CRC,3 4 or alternatively boost the response to chemotherapy, particularly the immune …
期刊介绍:
Gut is a renowned international journal specializing in gastroenterology and hepatology, known for its high-quality clinical research covering the alimentary tract, liver, biliary tree, and pancreas. It offers authoritative and current coverage across all aspects of gastroenterology and hepatology, featuring articles on emerging disease mechanisms and innovative diagnostic and therapeutic approaches authored by leading experts.
As the flagship journal of BMJ's gastroenterology portfolio, Gut is accompanied by two companion journals: Frontline Gastroenterology, focusing on education and practice-oriented papers, and BMJ Open Gastroenterology for open access original research.