Xinming Xu, Yi Guo, Lili Huang, Berty Ruping Song, Dan Chen, Fangfang Weng, Xueying Zheng, Yu Wen, Zhenyu Wu, Xiang Gao, Liang Sun
{"title":"整体/区域脂肪量与心脏代谢疾病轨迹之间的各种关联:一个非线性多态模型。","authors":"Xinming Xu, Yi Guo, Lili Huang, Berty Ruping Song, Dan Chen, Fangfang Weng, Xueying Zheng, Yu Wen, Zhenyu Wu, Xiang Gao, Liang Sun","doi":"10.1002/oby.24185","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study aimed to investigate the association of whole body/regional fat mass (FM) with cardiometabolic disease (CMD) trajectory.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We conducted a prospective analysis using the UK Biobank. The FM index (FMI), a surrogate for whole body FM, and regional FM (i.e., arm, leg, and trunk) were examined as exposures. A nonlinear multistate framework was used to evaluate the association between whole/regional FM and CMD trajectory.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among the 423,966 participants (mean age 56.1 [SD 8.10] years, 43.9% men) with a median follow-up of 13.5 years, varied associations were identified between whole/regional FM and transitions in the CMD trajectory. Upper body FM (i.e., arm and trunk) exhibited significant positive J-shaped associations in the transitions from first CMD (FCMD) or cardiometabolic multimorbidity to death; however, FMI and leg FM demonstrated L-shaped associations. Leg FM played a beneficial role in the transition from FCMD to death, with a hazard ratio of 0.950 (95% CI: 0.931–0.968) per 1 kg.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Body fat composition and distribution revealed various associations with CMD trajectory, highlighting their clinical importance. Upper body FM among those participants with FCMD or cardiometabolic multimorbidity demonstrated positive J-shaped associations toward death, providing no evidence of the “obesity paradox.”</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 1","pages":"198-208"},"PeriodicalIF":4.2000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The various associations between whole /regional fat mass and trajectory of cardiometabolic diseases: a nonlinear multistate model\",\"authors\":\"Xinming Xu, Yi Guo, Lili Huang, Berty Ruping Song, Dan Chen, Fangfang Weng, Xueying Zheng, Yu Wen, Zhenyu Wu, Xiang Gao, Liang Sun\",\"doi\":\"10.1002/oby.24185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study aimed to investigate the association of whole body/regional fat mass (FM) with cardiometabolic disease (CMD) trajectory.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We conducted a prospective analysis using the UK Biobank. 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The various associations between whole /regional fat mass and trajectory of cardiometabolic diseases: a nonlinear multistate model
Objective
This study aimed to investigate the association of whole body/regional fat mass (FM) with cardiometabolic disease (CMD) trajectory.
Methods
We conducted a prospective analysis using the UK Biobank. The FM index (FMI), a surrogate for whole body FM, and regional FM (i.e., arm, leg, and trunk) were examined as exposures. A nonlinear multistate framework was used to evaluate the association between whole/regional FM and CMD trajectory.
Results
Among the 423,966 participants (mean age 56.1 [SD 8.10] years, 43.9% men) with a median follow-up of 13.5 years, varied associations were identified between whole/regional FM and transitions in the CMD trajectory. Upper body FM (i.e., arm and trunk) exhibited significant positive J-shaped associations in the transitions from first CMD (FCMD) or cardiometabolic multimorbidity to death; however, FMI and leg FM demonstrated L-shaped associations. Leg FM played a beneficial role in the transition from FCMD to death, with a hazard ratio of 0.950 (95% CI: 0.931–0.968) per 1 kg.
Conclusions
Body fat composition and distribution revealed various associations with CMD trajectory, highlighting their clinical importance. Upper body FM among those participants with FCMD or cardiometabolic multimorbidity demonstrated positive J-shaped associations toward death, providing no evidence of the “obesity paradox.”
期刊介绍:
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.