IF 1.7 4区 医学 Q4 BIOPHYSICS
Song Xue, Tiandong Lu, Wenqing Hu, Zeyang Xia, Jun Zhang, Xinwu Lu, Jing Xiong
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引用次数: 0

摘要

目的分析胸腔内主动脉瓣修复术(TEVAR)中左锁骨下动脉(LSA)支架移植物在LSA血管重建后不同配置的血流动力学变化:为了进行数值模拟,根据TEVAR术后计算机断层扫描血管造影图像重建了一个LSA支架移植物逆行弯曲方向的三维胸主动脉几何模型,并修改和重建了四种可能的LSA移植物配置:三种直行配置(0、2和10毫米主动脉延伸)和一种逆行配置。分析了 LSA 的血液灌注、流场、血流动力学壁参数以及用 Liutex 方法观察到的涡流演变过程:结果:与基本结构相比,逆行结构的平均流量减少了 11.2%。当 LSA 支架移植物在主动脉腔内延伸时,可观察到血流分离,在收缩晚期,近端下动脉几何形状和延伸壁开始形成涡流结构。延伸长度和上游流入角越大,延伸部分后方流场附近壁上的 OSI 和 RRT 就越大:考虑到 LSA 灌注和血栓形成风险,建议在 TEVAR 中使用较短的主动脉内延伸长度和较小的 LSA 支架移植物流入角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of Left Subclavian Artery Stent Graft Geometry on Blood Hemodynamics in Thoracic Endovascular Aortic Repair.

Objective: To analyze the hemodynamic changes in different configurations of left subclavian artery (LSA) stent grafts after LSA endovascular reconstruction in thoracic endovascular aortic repair (TEVAR).

Methods: For numerical simulation, one 3D thoracic aortic geometry model with an LSA stent graft retrograde curved orientation was reconstructed from post-TEVAR computed tomography angiography images, and four potential LSA graft configurations were modified and reconstructed: three straight (0, 2 and 10 mm aortic extension) and one anterograde configuration. The blood perfusion of the LSA, flow field, hemodynamic wall parameters and vortex evolution process visualized by the Liutex method were analyzed.

Results: The average flow in the retrograde configuration decreased by 11.2% compared to that in the basic configuration. When the LSA stent graft extends in the aortic lumen, Flow separation is observed, and vortex structures begin to form at the proximal inferior arterial geometry and the wall of the extension in late systole. A greater extension length and inflow angle upstream resulted in a greater OSI and RRT on the nearby wall of the posterior flow field of the extension.

Conclusions: Shorter intra-aortic extension length and smaller LSA stent graft inflow angle may be recommended in TEVAR, considering LSA perfusion and thrombosis risk.

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来源期刊
CiteScore
3.40
自引率
5.90%
发文量
169
审稿时长
4-8 weeks
期刊介绍: Artificial Organs and Prostheses; Bioinstrumentation and Measurements; Bioheat Transfer; Biomaterials; Biomechanics; Bioprocess Engineering; Cellular Mechanics; Design and Control of Biological Systems; Physiological Systems.
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