IF 1.9 4区 医学 Q3 GENETICS & HEREDITY
Yun Lan, Linghua Li, Mingfeng Xiao, Yaqing Lin, Xuemei Ling, Feng Li, Fengyu Hu
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引用次数: 0

摘要

1 型人类免疫缺陷病毒(HIV-1)的特点是遗传多样性极高。不同亚型在同一人群中的传播往往会导致循环重组型(CRF)和独特重组型(URF)的出现。目前,中国的HIV-1重组亚型主要来源于CRF07_BC、CRF01_AE、CRF55_01B和B亚型。在此,我们从广东省的8名HIV-1感染者中获得了近全长基因组(NFLGs),这些基因组具有高度相似的重组模式,涉及2个CRF01_AE、1个CRF07_BC和2个B亚型片段。这 8 个 NFLG 序列拥有以下 4 个相似的断点:根据 HXB2 参考序列,它们分别拥有 1220 个核苷酸(nt)、2243 个核苷酸(nt)、2673 个核苷酸(nt)和 5820 个核苷酸(nt),因此被归类为 CRF162_cpx。这是中国首个由 CRF01_AE、CRF07_BC 和 B 亚型衍生的复合 CRF。贝叶斯推断表明,HIV-1 CRF162_cpx大约起源于2010-2015年。CRF162_cpx的出现表明,中国东南地区的HIV多样性在不断积累和演变。因此,应加强对 HIV-1 分子流行病学的监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic characterization of a novel HIV-1 circulating recombinant form (CRF162_cpx) involving CRF01_AE, CRF07_BC and subtype B in Guangdong, China.

Human immunodeficiency virus type 1 (HIV-1) is characterized by its extremely high level of genetic diversity. The spread of different subtypes in the same population often leads to the emergence of circulating recombinant forms (CRFs) and unique recombinant forms (URFs). At present, the main recombinant subtypes of HIV-1 in China originate from CRF07_BC, CRF01_AE, CRF55_01B and subtype B. Here, we obtained the nearly full-length genomes (NFLGs) from eight HIV-1 infected patients in Guangdong Province, which shared highly similar recombinant patterns, involving two CRF01_AE, one CRF07_BC and two subtype B segments. The eight NFLG sequences own four similar breakpoints as follows: 1220 nucleotide (nt), 2243 nt, 2673 nt, and 5820 nt according to the HXB2 reference sequence, and they therefore were assigned as CRF162_cpx. This is the first complex CRF derived from CRF01_AE, CRF07_BC and subtype B in China. The Bayesian inference of the segments showed that HIV-1 CRF162_cpx was inferred to have approximately originated around 2010-2015. The emergence of CRF162_cpx indicates that the HIV diversity in southeast China constantly accumulates and evolves. Thus, intensive surveillance of HIV-1 molecular epidemiology should be reinforced.

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来源期刊
Virus Genes
Virus Genes 医学-病毒学
CiteScore
3.30
自引率
0.00%
发文量
76
审稿时长
3 months
期刊介绍: Viruses are convenient models for the elucidation of life processes. The study of viruses is again on the cutting edge of biological sciences: systems biology, genomics, proteomics, metagenomics, using the newest most powerful tools. Huge amounts of new details on virus interactions with the cell, other pathogens and the hosts – animal (including human), insect, fungal, plant, bacterial, and archaeal - and their role in infection and disease are forthcoming in perplexing details requiring analysis and comments. Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses.
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