IF 3.8 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Henri Trang, Tim J Hartung, Qianlan Chen, Stefan Hetzer, Claudia Chien, Pia S Sperber, Tanja Schmitz-Hübsch, Susanna Asseyer, Rebekka Rust, Darius Mewes, Lina Anderhalten, Michael Sy, Alexander U Brandt, Carsten Finke, Friedemann Paul
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引用次数: 0

摘要

定量磁共振成像(qMRI)涉及以对组织学特性敏感的标准化单位绘制微观结构图,是对传统磁共振成像的补充,传统磁共振成像依赖于对比度加权图像,而对比度加权图像的强度没有生物物理意义。虽然在疾病情况下需要测量髓鞘、铁或水含量等组织特性,但 qMRI 的变化通常可能反映出衰老或临床前变性的混合影响。我们在 3T 下使用了适用于临床常规的快速多参数映射 (MPM) 方案,以 1.6 毫米的各向同性分辨率重建了磁化传递饱和度 (MT)、质子密度 (PD)、纵向 (R1) 和横向弛豫率 (R2*) 的全脑定量映射。我们报告了来自健康人群的 MPM 参考值,这些人群的年龄和性别分布在全脑白质(WM)、T2 加权 WM 高密度、皮质灰质和深部灰质区域中具有典型的多发性硬化症特征,并介绍了后处理优化方法,包括病变整合和 PD 图与脑脊液(CSF)的归一化,用于多发性硬化症(MS)以及相关疾病的标准化研究。通过使用 WM 校准,PD 图受到多发性硬化症中 WM 异常的影响。研究结果承认非线性年龄效应对多发性硬化症的影响,并建议在多发性硬化症的未来临床应用中使用 CSF 校准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A quantitative multi-parameter mapping protocol standardized for clinical research in multiple sclerosis.

Quantitative magnetic resonance imaging (qMRI) involves mapping microstructure in standardized units sensitive to histological properties and supplements conventional MRI, which relies on contrast weighted images where intensities have no biophysical meaning. While measuring tissue properties such as myelin, iron or water content is desired in a disease context, qMRI changes may typically reflect mixed influences from aging or pre-clinical degeneration. We used a fast multi-parameter mapping (MPM) protocol for clinical routine at 3T to reconstruct whole-brain quantitative maps of magnetization transfer saturation (MT), proton density (PD), longitudinal (R1), and transverse relaxation rate (R2*) with 1.6 mm isotropic resolution. We report reference MPM values from a healthy population with age and gender distributions typical of multiple sclerosis in whole brain white matter (WM), T2-weighted WM hyperintensities, cortical grey matter and deep grey matter regions and present post-processing optimizations including integration of lesions and normalization of PD maps against cerebrospinal fluid (CSF) for standardized research in multiple sclerosis (MS) and potentially also in related disorders. PD maps were affected by WM abnormalities in MS using WM calibration. The results acknowledge the impact of non-linear age effects on MPM and suggest using CSF calibration for future clinical application in MS.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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