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IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-16 DOI:10.1080/14786419.2024.2442102

Tian-Yi Liu, Hong-Li Liu, Xi Jiang, Qiong Liu, Jing-Jie Bai, Ze-Ying Guo, Zheng Zhang, Ji-Hai Shang, Cheng-Shan Yuan

引用次数: 0

摘要

从 Croton cascarilloides Raeusch 的叶子和小枝中分离出了两种新的倍半萜桉叶烷内酯，即 5α-hydroxy-eudesman-7(11)-en-8α(12)-olide (1) 和 5α-hydroxy-7(11)-en-8-oxo-eudesmane (2)，以及六种已知的倍半萜桉叶烷内酯。根据核磁共振和质谱分析确定了这些化合物的结构。对分离出的化合物的细胞毒性活性进行了评估。化合物 6（IC50 115.38 ± 8.81 μg/mL）和化合物 8（IC50 72.04 ± 1.92 μg/mL）对 HL-60 白血病细胞具有抑制活性，而化合物 2 对 HL-60 白血病细胞（IC50 178.34 ± 6.43 μg/mL）和 SMMC-7721 肝癌细胞（IC50 188.87 ± 7.40 μg/mL）均具有抑制活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Two new sesquiterpene eudesmanolides from the Croton cascarilloides Raeusch.

Two new sesquiterpene eudesmanolides, 5α-hydroxy-eudesman-7(11)-en-8α(12)-olide (1), and 5α-hydroxy-7(11)-en-8-oxo-eudesmane (2), along with six known sesquiterpene eudesmanolides, were isolated from the leaves and twigs of Croton cascarilloides Raeusch. The structures of these compounds were established basis on NMR and MS spectroscopic analyses. The cytotoxic activities of the isolated compounds were evaluated. Compounds 6 (IC₅₀ 115.38 ± 8.81 μg/mL) and 8 (IC₅₀ 72.04 ± 1.92 μg/mL) showed inhibitory activity against HL-60 leukaemia cells, while compounds 2 exhibited inhibitory activity against both HL-60 leukaemia cells (IC₅₀ 178.34 ± 6.43 μg/mL) and SMMC-7721 hepatoma cells (IC₅₀ 188.87 ± 7.40 μg/mL).

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.